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Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus |
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| Authors: | Cho Jun-Young Kwon Yun-Ju Sohn Mi-Jin Seok Soon-Ja Kim Won-Gon |
| Affiliation: | a Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yusong, Daejeon 305-806, Republic of Korea b National Institute of Agricultural Science and Technology, RDA, Suwon 441-707, Republic of Korea |
| Abstract: | A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC50 of 6 μM and also showed antibacterial activity against S. aureus and MRSA. |
| Keywords: | Hispidin Enoyl-ACP reductase Inhibitor Antibacterial Staphylococcus aureus Phellinus linteus |
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