The Role of Fluoroquinolones in the Promotion of Alginate Synthesis and Antibiotic Resistance in Pseudomonas aeruginosa |
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Authors: | Sophia E Piña Stephen J Mattingly |
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Institution: | (1) Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284, USA , US |
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Abstract: | Treatment of nonmucoid Pseudomonas aeruginosa with gyrase inhibitors such as ciprofloxacin, norfloxacin, and ofloxacin, which target the A subunit of topoisomerase II,
resulted in 100% conversion to the mucoid phenotype. However, antibiotics that partially inhibited growth and macromolecular
synthesis (DNA, RNA, protein, or peptidoglycan) of nonmucoid isolates in a gluconate-limited chemostat culture system did
not promote conversion to mucoid subpopulations. An increase in resistance was observed in populations that expressed the
mucoid phenotype. Both mucoid conversion and antibiotic resistance were completely reversible when ciprofloxacin pressure
was withdrawn, but only partially reversible by the removal of norfloxacin and ofloxacin. Thus, these experiments indicate
that in the presence of some fluoroquinolones, a conditional response resulting in mucoid conversion and antibiotic resistance
may occur.
Received: 28 January 1997 / Accepted: 12 February 1997 |
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Keywords: | |
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