Nanogold-Gallate Chitosan-Targeted Pulmonary Delivery for Treatment of Lung Cancer |
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| Authors: | Seamkwan Komenek Urarika Luesakul Sanong Ekgasit Tirayut Vilaivan Narong Praphairaksit Songchan Puthong Nongnuj Muangsin |
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| Institution: | 1.Department of Chemistry, Faculty of Science,Chulalongkorn University,Bangkok,Thailand;2.Antibody Production Research Unit, Institute of Biotechnology and Genetic Engineering,Chulalongkorn University,Bangkok,Thailand |
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| Abstract: | Lung cancer is one of the most of cancer type founds and a leading cause of death worldwide. Through the development of new candidate compound (3,4,5-tribenzyloxybenzoic acid (GAOBn)) and a drug delivery system of our design of quaternized chitosan-gallic acid-folic acid stabilized gold nanoparticles (Au@QCS-GA-FA) as the targeted nanocarrier for treatment of lung cancer, we have found that GAOBn not only showed high cytotoxicity against lung cancer cells (CHAGO) with more than tenfold than cisplatin, but also showed low toxicity against normal cells (CRL-1947). The combination Au@QCS-GA-FA/GAOBn showed highly efficient cellular uptake and localization of gold nanoparticles via the active targeting of cancer cells. This established the potential of Au@QCS-GA-FA as a nanocarrier for anticancer agent-targeted delivery for treatment of lung cancer. |
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