Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord |
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Authors: | K Kangawa N Minamino A Fukuda H Matsuo |
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Institution: | 1. Department of Biochemistry, Miyazaki Medical College, Kiyotake, Miyazaki 889-16, Japan;2. Department of Anesthesiology, Miyazaki Medical College, Kiyotake, Miyazaki 889-16, Japan |
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Abstract: | A new peptide, designated "neuromedin K" has been discovered and isolated from porcine spinal cord by using bioassays for a tachykinin-like effect on the contractility of smooth muscle preparation from guinea-pig ileum. Porcine neuromedin K has been identified by microsequencing as: Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2. The sequence thus determined has been confirmed by synthesis. Neuromedin K has been found to have not only a remarkable sequence homology to kassinin and substance P, but also a prompt stimulant activity on guinea-pig ileum in a manner similar to that of substance P, suggesting that neuromedin K may be involved in neural transmission. |
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