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Recent advances in nanobiotechnology and high-throughput molecular techniques for systems biomedicine
Authors:Eung-Sam Kim  Eun Hyun Ahn  Euiheon Chung  Deok-Ho Kim
Affiliation:1. Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA
2. Department of Medical System Engineering, Gwangju Institute of Science and Technology, Gwangju, 500-712, Korea
3. Department of Pathology, School of Medicine, University of Washington, Seattle, WA, 98195, USA
4. Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, 98109, USA
5. School of Mechatronics, Gwangju Institute of Science and Technology, Gwangju, 500-712, Korea
6. Center for Cardiovascular Biology, University of Washington, Seattle, WA, 98109, USA
Abstract:Nanotechnology-based tools are beginning to emerge as promising platforms for quantitative high-throughput analysis of live cells and tissues. Despite unprecedented progress made over the last decade, a challenge still lies in integrating emerging nanotechnology-based tools into macroscopic biomedical apparatuses for practical purposes in biomedical sciences. In this review, we discuss the recent advances and limitations in the analysis and control of mechanical, biochemical, fluidic, and optical interactions in the interface areas of nanotechnologybased materials and living cells in both in vitro and in vivo settings.
Keywords:bioimaging   microarray   microfluidics   nanomaterials   nanotechnology   next generation DNA sequencing   quantum dot
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