TGFBIp/betaig-h3 protein: a versatile matrix molecule induced by TGF-beta |
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Authors: | Thapa Narendra Lee Byung-Heon Kim In-San |
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Institution: | aCell and Matrix Research Institute, Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, 101 Dongin-Dong, Jung-gu, Daegu 700-422, Republic of Korea |
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Abstract: | TGFBIp/βig-h3 protein is an extracellular matrix molecule initially cloned from human adenocarcinoma cells treated with TGF-β. Its precise function remains obscure but a number of studies have demonstrated it to be an intriguingly versatile molecule role in a wide range of physiological and pathological conditions. To date, the most extensively studied and reported action of TGFBIp/βig-h3 protein is in corneal dystrophy and several excellent reviews are available on this. Work from various laboratories on this molecule has compiled a tremendous amount of information over the past decade and a half. Here we review the current understanding on TGFBIp/βig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation. |
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Keywords: | TGFBI βig-h3 FAS1 domain Integrin Cell adhesion Tumorigenesis Angiogenesis Inflammation Osteogenesis Nephropathy Wound healing |
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