Antiangiogenic,anti-inflammatory and their antioxidant activities of Turnera subulata Sm. (Turneraceae) |
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| Institution: | 1. Dept. of Biotechnology, Hindusthan College of Arts and Science, Coimbatore 641028, TN, India;2. Biological Material Laboratory, CSIR-Central Leather Research Institute (CLRI), Chennai 600020, TN, India;3. Dept. of Physics, Thiruvalluvar University, TUCAS Campus, Thennangur, 604408 Vellore, TN, India;4. UNESCO UNISA Africa Chair in Nanosciences & Nanotechnology, College of Graduate Studies, University of South Africa, Muckleneuk Ridge, PO Box 392, Pretoria, South Africa;5. Nanosciences African Network (NANO-AFNET), iThemba LABS-National Research Foundation, 1 Old Faure Road, Somerset West, PO Box 722, Cape Town 7129, South Africa;1. School of Biological and Environmental Sciences, Faculty of Sciences, Shoolini University, Solan, Himachal Pradesh 173229, India;2. Department of Pharmacognosy, CSGA (Agrosup/CNRS/INRAE/UBFC), UFR of Health Sciences, University of Bourgogne Franche-Comté, Dijon, France;3. Department of Biotechnology, MMEC, Central Research Cell, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana 133203, India;4. University Institute of Biotechnology, Chandigarh University, Gharuan, Mohali, Punjab 140413, India;5. Department of Natural Products, NIPER-A, Opposite Air Force Station, Palaj, Gandhinagar, Gujarat 382355 India;6. Yeast Biology Group, DBT-ICGEB Centre for Advanced Bio Energy Research, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India;7. Department of Life Sciences (Botany), Manipur University, Imphal 795003, India |
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| Abstract: | Turnera subulata is a substantial medicinal plant used in folk medicine to treat various ailments. The current study was assess the total phenolic and flavonoid contents to evaluate the antioxidant and anti-inflammatory activities of the sequentially extracted T. subulata plant samples. In vitro anti-angiogenic activity was evaluated by chick chorioallantoic membrane (CAM) model for chloroform, ethyl acetate and ethanol extracts. The results obtained revealed that total phenolic content of the chloroform extract (24.13 ± 0.27 mg/g) and total flavonoid content (TFC) of the chloroform extract (22.28 ± 0.40 mg/g) were found to be suggestively higher than the other extracts. A strong antioxidant property was observed for all the six extracts. A study anti-inflammatory activity was observed in chloroform and ethanol extracts, with IC50 ranging from 79 ± 1.01 μg/mL to 81 ± 1.01 μg/mL for protein denaturation assay and from 74 ± 0.11 μg/mL to 76 ± 1.11 μg/mL for HRBC membrane stabilization assay, respectively. The chloroform and ethanol extracts have exhibited good antiangiogenic property. Eventually, these results justified that the chloroform and ethanol extracts of T. subulata with great antioxidant, anti-inflammatory and antiangiogenesis potentials could be promising candidates for the development of a cost effective, potent anticancer drug with minimal side effects. |
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| Keywords: | Antioxidant Anti-inflammatory Antiangiogenesis Chick chorioallantoic membrane (CAM) |
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