Improved therapeutic efficiency of photothermal treatment and nursing care in prostate cancer by DOX loaded PEG coated Cu@Se nano-hybrid vesicle |
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| Institution: | 1. Department of Nursing Care, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China;2. Department of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China;3. Department of Orthopeadic Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China;1. Deparment of Chemistry and Chemical Processing Technologies, Mersin University, 33343, Mersin, Turkey;2. Deparment of Chemistry and Chemical Processing Technologies, Dicle University, 21280, Diyarbak?r, Turkey;3. Food Processing Programme, Mersin University, 33343, Mersin, Turkey;4. Deparment of Chemistry and Chemical Processing Technologies, Siirt University, 56100, Siirt, Turkey;5. Chemistry Department, Sciences Faculty, Erciyes University, 38039, Kayseri, Turkey;6. Technology Research & Application Center (TAUM), Erciyes University, 38039, Kayseri, Turkey;1. Engineering Research Center of Bio-Process of Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, PR China;2. Hefei Preschool Education College, Hefei, 230013, PR China;1. College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, 310015, PR China;2. Institute of Quality and Standard for Agriculture Products, Zhejiang Academy of Agricultural Science, Hangzhou, 310021, PR China;3. School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China |
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| Abstract: | Cancer is one of the major life threatening diseases, with higher mortality rate and morbidity. It is always a challenge for effective drug delivery and release of drug in specific tumor sites. Therefore to identify the synergistic effect of chemotherapeutic drug and photo thermal agent on tumor area, Doxorubicin (DOX) acts as anticancer agent but it has low aqueous solubility so its clinical application is limited. The present study developed doxorubicin (DOX) were designed to be with the poly ethylene glycol (PEG) functionalized copper and selenium (Cu-Se) nanoparticles (PEG@Cu-Se+DOX) and it is efficiently synthesized and enhance its aqueous formulation and improve the prostate cancer (DU145 and LNCaP) activity. The characteristics like mono dispersity, size stability and constant spectral of as-synthesized nanoparticles are comparably excellent than DOX alone. Also the enhanced cellular uptake and in vitro cytoxicicty suggests these nanoparticles selectively killing prostate cancer. In this present study explained that PEG@Cu-Se+DOX as a safe and hopeful strategy for chemotherapeutics of photothermal therapy and deserve for further clinical evaluations. |
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| Keywords: | Drug delivery (Cu-Se) Nursing care Prostate cancer |
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