Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery |
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| Institution: | 1. Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Straße 11, 44227 Dortmund, Germany;2. Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Straße 6, 44221 Dortmund, Germany;1. School of Chemical Engineering, Sichuan Uiversity, Chengdu 610065, China;2. School of Life Sciences, University of Science and Technology of China, Hefei 230026, Anhui, China;1. School of Food Science, Guangdong Pharmaceutical University, Zhongshan, Guangdong Province 528458, China;2. School of Public Health (Shenzhen), Sun Yat-sen University, Guangdong Province 510080, China;3. Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, Guangdong Province 510080, China;4. Guangdong Province Engineering Laboratory for Nutrition Translation, Guangzhou, Guangdong Province 510080, China;5. Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China |
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| Abstract: | Through evolution, nature has provided natural products (NPs) as a rich source of diverse bioactive material. Many drug discovery programs have used nature as an inspiration for the design of NP-like compound classes. These concepts are guided by the prevalidated biological relevance of NPs while going beyond the limitations of nature to produce chemical matter that could have unexpected or novel bioactivities. Herein, we discuss, compare, and highlight recent examples of NP-inspired methods with a focus on the pseudo-NP concept. |
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| Keywords: | Small molecules Natural products Chemical biology Ring distortion Biology-oriented synthesis Pseudo-natural products |
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