Dynamic stability of signal transduction networks depending on downstream and upstream specificity of protein kinases |
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Authors: | Binder Bernd Heinrich Reinhart |
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Institution: | (1) Theoretical Biophysics, Institute of Biology, Math.-Nat. Dept. I, Humboldt University Berlin, Invalidenstr. 43, D-10115 Berlin, (Germany) |
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Abstract: | Mathematical methods are used for explaining the structural design of signal transduction networks, e.g. MAP kinase cascades, which control cell proliferation, differentation or apoptosis. Taking into account protein kinases and phosphatases the interrelation between the topology of signaling networks and the stability of their ground state are analysed. It is shown that the stability is closely related to the system's dimension and to the number of cycles within the network. Systems with a higher number of kinases and/or cycles tend to be more unstable. In contrast to that increasing phosphatase activity stabilises the ground state. |
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Keywords: | signaling network dynamical stability ground state MAP kinases specificity digraphs cycles |
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