Effect of phosphorus dendrimers on DMPC lipid membranes |
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Authors: | Ionov Maksim Wróbel Dominika Gardikis Konstantinos Hatziantoniou Sophia Demetzos Costas Majoral Jean-Pierre Klajnert Barbara Bryszewska Maria |
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Institution: | Department of General Biophysics, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland. maksion@biol.uni.lodz.pl |
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Abstract: | Large unilamellar liposomes and multilamellar vesicles consisting of DMPC interacted with cationic phosphorus-containing dendrimers CPDs G3 and G4. DSC and ζ-potential measurements have shown that liposomal-dendrimeric molecular recognition probably occurs due to the interaction between the complementary surface groups. Calorimetric studies indicate that the enthalpy of the transition of the lipids that interact with CPDs is dependent on the dendrimers generation. These results can be used in order to rationally design mixed modulatory liposomal locked-in dendrimeric, drug delivery nano systems. |
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