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Genetic markers for the Booroola fecundity (Fec) gene in sheep |
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| Authors: | I Lanneluc R D Drinkwater J M Elsen D J S Hetzel T C Nguyen L R Piper J Thimonier B Harrison J Gellin |
| Institution: | (1) Laboratoire de Génétique Cellulaire, INRA, BP 27, 31326 Castanet-Tolosan Cedex, France;(2) CSIRO, Division of Tropical Animal Production, University of Queensland, 4072 Brisbane, Queensland, Australia;(3) Station d'Amélioration Génétique des Animaux, INRA, BP 27, 31326 Castanet-Tolosan Cedex, France;(4) Division of Animal Production, CSIRO, Armidade, New South Wales, Australia;(5) Laboratoire d'Analyse des Groupes Sanguins, INRA, 78352 Jouy-en-Josas Cedex, France;(6) ENSAM-INRA, 2 Place Viala, 34060 Montpellier Cedex 01, France |
| Abstract: | Animals from the Booroola line of Australian Merino sheep are characterized by a high ovulation rate that can be attributed to the presence of a codominant allele (Fec B).The specific function of the gene has not been identified. Effective use of the trait within the sheep breeding industry requires one or more genetic markers that can distinguish between alternative alleles at the locus Fec. With a combination of DNA minisatellite markers and polymorphic protein markers, a cluster of seven minisatellite fragments has been identified as being linked to the Fec gene and to the ovine A blood group locus. The minisatellite fragments have been derived from multilocus probes and hence cannot be used to define the chromosomal location of the Fec gene or to serve as diagnostic markers for Fec. The derivation of cloned single locus markers from the minisatellite fragments will enable finer scale mapping of the Fec and the A blood group locus in sheep. |
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