| 单侧甲状腺电凝毁损法构建大鼠亚临床甲状腺功能减退症模型 |
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| 引用本文： | 葛金芳,赵斌,彭磊,吴婷妮,解雪峰,胡成穆.单侧甲状腺电凝毁损法构建大鼠亚临床甲状腺功能减退症模型[J].中国实验动物学报,2011,19(1):56-58,95. |
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| 作者姓名： | 葛金芳 赵斌 彭磊 吴婷妮 解雪峰 胡成穆 |
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| 作者单位： | 安徽医科大学药学院,合肥,230032 |
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| 基金项目： | 安徽省教育厅自然科学基金重点项目 |
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| 摘 要： | 目的评价单侧甲状腺电凝毁损法建立大鼠亚临床甲状腺功能减退症模型的可行性。方法 36只Wistar大鼠随机分为假手术组、亚临床甲状腺功能减退症组和临床甲状腺功能减退症组。亚临床甲状腺功能减退症组大鼠电凝毁损单侧甲状腺,临床甲状腺功能减退症组大鼠电凝毁损全部甲状腺,假手术组暴露甲状腺而不毁损。饲养2周后,相同时间组间平行采血、化学发光法检测血清TSH、fT4、T3水平,光镜下观察亚临床甲状腺功能减退症组大鼠对侧甲状腺组织病理形态学变化。结果与假手术组比较,大鼠单侧电凝毁损甲状腺术后2周血清TSH水平轻度升高而T3、fT4则无显著变化,残留甲状腺组织轻度增生,符合亚临床甲状腺功能减退症的特征;大鼠双侧电凝毁损甲状腺2周后血清T3、fT4显著下降、TSH水平显著升高,符合临床甲状腺功能减退症的诊断标准。结论单侧甲状腺电凝毁损法建立大鼠亚临床甲状腺功能减退症模型是用于研究亚临床甲状腺功能减退症发生及发展机制的简便可靠模型。
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| 关 键 词： | 亚临床甲状腺功能减退症 亚临床甲减 亚甲减 模型 甲状腺 |
Establishment of a rat model of subclinical hypothyroidism by hemi-thyroid electrocoagulation |
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| GE Jin-fang,ZHAO Bin,PENG Lei,WU Ting-ni,XIE Xue-feng,HU Cheng-mu.Establishment of a rat model of subclinical hypothyroidism by hemi-thyroid electrocoagulation[J].Acta Laboratorium Animalis Scientia Sinica,2011,19(1):56-58,95. |
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| Authors: | GE Jin-fang ZHAO Bin PENG Lei WU Ting-ni XIE Xue-feng HU Cheng-mu |
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| Institution: | GE Jin-fang,ZHAO Bin,PENG Lei,WU Ting-ni,XIE Xue-feng,HU Cheng-mu(School of Pharmacy,Anhui Medical University,Hefei 230032,China) |
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| Abstract: | Objective To investigate the feasibility of hemi-thyroid electrocoagulation in the establishment of a rat model of subclinical hypothyroidism(SCH).Methods Thirty-six young Wistar rats were randomly divided into three groups including sham,subclinical hypothyroidism,and clinical hypothyroidism(CH) groups.The rats in SCH group were given hemi-thyroid electriocoagulation,rats in CH group were given total thyroid electrocoagulation,while rats in the sham group only exposed thyroid without electrocoagulation.2 w... |
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| Keywords: | Thyroid Rat Subclinical hypothyroidism(SCH) Model Electrocoagulation |
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