Cloning and Characterization of a Novel Mouse Short-Chain Dehydrogenases/Reductases cDNA, mHsdl2, Encoding a Protein with an SDR Domain and an SCP2 Domain |
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| Authors: | Dai Jianfeng Li Pingxin Ji Chaoneng Feng Congjing Gui Min Sun Yaqiong Zhang Jiyuan Zhu Jiangyan Dou Chao Gu Shaohua Xie Yi Mao Yumin |
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| Affiliation: | (1) State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, 200433, People's Republic of China;(2) School of Pharmacology, The Second Military Medical University, Shanghai, 200433, People's Republic of China |
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| Abstract: | The short-chain dehydrogenases/reductases (SDRs) play an important role in the body's metabolism. We have cloned a novel mouse SDR cDNA, which encodes a deduced HSD-like protein with a conserved SDR domain and an SCP2 domain. The 1.8 kb cDNA consists of 11 exons and is mapped to mouse chromosome 4B3. The corresponding gene is widely expressed in normal mouse tissues and its expression level in the liver increases after inducement with cholesterol food. The predicted mouse HSDL2 protein, which has a peroxisomal target signal, is localized in the cytoplasm of NIH 3T3 cells. |
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| Keywords: | SDR SCP2 mHsdl2 expression pattern subcellular localization |
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