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Cloning and Characterization of a Novel Mouse Short-Chain Dehydrogenases/Reductases cDNA, mHsdl2, Encoding a Protein with an SDR Domain and an SCP2 Domain
Authors:Dai Jianfeng  Li Pingxin  Ji Chaoneng  Feng Congjing  Gui Min  Sun Yaqiong  Zhang Jiyuan  Zhu Jiangyan  Dou Chao  Gu Shaohua  Xie Yi  Mao Yumin
Affiliation:(1) State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, 200433, People's Republic of China;(2) School of Pharmacology, The Second Military Medical University, Shanghai, 200433, People's Republic of China
Abstract:The short-chain dehydrogenases/reductases (SDRs) play an important role in the body's metabolism. We have cloned a novel mouse SDR cDNA, which encodes a deduced HSD-like protein with a conserved SDR domain and an SCP2 domain. The 1.8 kb cDNA consists of 11 exons and is mapped to mouse chromosome 4B3. The corresponding gene is widely expressed in normal mouse tissues and its expression level in the liver increases after inducement with cholesterol food. The predicted mouse HSDL2 protein, which has a peroxisomal target signal, is localized in the cytoplasm of NIH 3T3 cells.
Keywords:SDR  SCP2  mHsdl2   expression pattern  subcellular localization
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