| 迷走背核微量注射P物质抑制大鼠胃肌电活动和胃运动 |
| |
| 作者姓名： | Peng Y Lin KW |
| |
| 作者单位： | 大连医科大学生理教研室!大连,116027,大连医科大学生理教研室!大连,116027 |
| |
| 摘 要： | 本工作观察到大鼠迷走背核微量注射Ｐ物质（Ｓｕｂｓｔａｎｃｅ Ｐ,ＳＰ）抑制胃肌电快波和胃运动。该效应可分别迷走背核注射ＳＰ抗血清,ＳＰ受体拮抗剂「Ａｒｇ＾６,Ｄ－Ｔｒｐ＾７,９,Ｎ－Ｍｅ－Ｐｈｅ＾８」－ＳＰ６－１１或切断迷走神经所消除。用利血平耗竭交感神经递质则不影响该效应。
|
| 关 键 词： | 迷走背核 P物质 胃肌电 胃运动 SP抗血清 |
Inhibition of gastric myoelectric activity and gastric motility by microinjection of substance P into dorsal vagal nucleus in rats |
| |
| Peng Y,Lin KW.Inhibition of gastric myoelectric activity and gastric motility by microinjection of substance P into dorsal vagal nucleus in rats[J].Acta Physiologica Sinica,1999,51(5):557-563. |
| |
| Authors: | Peng Y Lin K W |
| |
| Institution: | Department of Physiology, Dalian Medical University, Dalian 116027. |
| |
| Abstract: | The Present inveshgation showed tha ndcroinjechon of substance P (SP) into dohalVagal nucleus inhibited gastric mpelectric fast wav and gastric rnohlity. The effect coLildbe blocked by SP antisennn or SP antagonist Arg, D-Trp7,9, N-Me-Phe8 ]-SP6-11 orvagotomy. Depletion of sympathehc hansndtters by reserpine did not det induchon ofthe idebihon. The results indicate tha both exognous and endogenous SP of dorsal vagalnucleus decrease the gastric myoelectric fast wav and mohlity, Which is mediated byvagus nerve. |
| |
| Keywords: | dorsal vagal nucleus substance P gastric myoelectric fast wave gastric motility SP antiserum SP antagonist |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
|
