Metabolite profiles of Stachybotrys isolates from water-damaged buildings and their induction of inflammatory mediators and cytotoxicity in macrophages |
| |
| Authors: | Nielsen Kristian Fog Huttunen Kati Hyvärinen Anne Andersen Birgitte Jarvis Bruce B Hirvonen Maija-Riitta |
| |
| Institution: | (1) The Mycology Group, BioCentrum-DTU,Building 221, Technical University ofDenmark, DK-2800 Kgs. Lyngby, Denmark;(2) Energy and Indoor Climate Division, Danish BuildingResearch Institute, Dr. Neergaardsvej 15, DK-2970 Horsholm, Denmark;(3) Department of Environmental Health, National PublicHealth Institute, P.O. Box. 95, FIN-70701 Kuopio, Finland;(4) Department of Chemistry and Biochemistry and theJoint Institute for Food Safety and Applied Nutrition (JIFSAN), University of Maryland, College Park, MD 20742, USA |
| |
| Abstract: | The metabolite profiles of 20 Stachybotrys spp.isolates from Finnish water-damaged buildings were compared with their biological activities. Effects of purified compounds
on cytotoxicity and production of inflammatory mediators such as nitric oxide, IL-6 and TNFα in murine RAW264.7 macrophage
cells were studied. The 11isolates belonging to the satratoxin-producing chemotype were highly cytotoxic to the macrophages.
The isolates inducing inflammatory mediators all belonged to the atranone-producing chemotype, but pure atranones B, and D
did not elicit a response in the bioassay. Altogether, cytotoxicity ofStachybotrys sp. isolates appear to be related to satratoxin production whereas the specific component inducing inflammatory responses
in atranone-producing isolates remains obscure.
This revised version was published online in June 2006 with corrections to the Cover Date. |
| |
| Keywords: | Atranones satratoxins mycotoxin Stachybotrys inflammation TNFα IL-6 |
| 本文献已被 SpringerLink 等数据库收录！ |
|
