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Alpha-1-antitrypsin immunoreactivity in islet cells of adult human pancreas |
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| Authors: | Dr. M. B. Ray V. J. Desmet W. Gepts |
| Affiliation: | (1) Departement Medische Navorsing, Academisch Ziekenhuis Sint Rafaël, Laboratorium voor Histochemie en Cytochemie, Leuven, Belgium;(2) Laboratorium voor Anatomopathologie Universitair Ziekenhuis Brugman, Brussel, Belgium;(3) Departement Medische Navorsing, Academisch Ziekenhuis Sint Rafaël, Laboratorium voor Histochemie en Cytochemie, B-3000 Leuven, Belgium |
| Abstract: | alpha-1-antitrypsin immunoreactivity was demonstrated by immunofluorescence technique in the peripheral islet cells of all ten normal adult human pancreata examined; normal adult human liver was negative. The specificity of the reactions was confirmed by applying various control tests including absorption of the specific antisera with purified alpha-1-antitrypsin, inhibition and blocking tests and by ensuring the monospecificity of the antisera used. The findings suggest that the pancreatic islet may be an additional source of alpha-1-antitrypsin. |
| Keywords: | Pancreas (Human) Islet cells Alpha-1-antitrypsin Immunofluorescence |
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