The role of centrosomes in fertilization,cell division and establishment of asymmetry during embryo development |
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| Authors: | Heide Schatten Qing-Yuan Sun |
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| Institution: | 1. Department of Veterinary Pathobiology, University of Missouri-Columbia, 1600 E Rollins Street, Columbia, MO 65211, USA;2. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing 100101, PR China;1. Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, United States;2. Department of Biological Sciences, California State University, East Bay, Hayward, CA 94542, United States;3. Neuroscience Training Program, University of Wisconsin, Madison, WI 53706, United States;1. University of Paris, CEA, INSERM, Institut de Recherche Saint Louis, UMRS1160-HIPI, CytoMorpho Lab, Avenue Claude Vellefaux, 75010 Paris, France;2. CIRB, Collège de France, UMR7241/U1050, Place Marcelin Berthelot, 75005 Paris, France;3. Institut Curie, PSL Research University, CNRS, UMR 144, Paris, France;4. Institut Pierre Gilles de Gennes, PSL Research University, Paris, France;5. University of Grenoble-Alpes, CEA, CNRS, INRA, Interdisciplinary Research Institute of Grenoble, UMR5168-LPCV, CytoMorpho Lab, Avenue des Martyrs, 38054 Grenoble, France |
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| Abstract: | Centrosomes play significant central roles during reproduction, cell division, embryo development and stem cell biology, and a wealth of new information has been accumulated during the past decade that spans molecular details and newly discovered functions/dysfunctions for specific centrosome proteins in various cellular activities. The present review will focus on the current state of knowledge on the role of germ cell centrosomes during fertilization, formation of the zygote centrosome, centrosome duplication and separation during first embryonic cell division, and asymmetric cell divisions during cell differentiation and subsequent embryo development. It will also address asymmetric cell division in stem cells and formation of the primary cilium during embryo development. |
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