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Noncooperative Interactions between Transcription Factors and Clustered DNA Binding Sites Enable Graded Transcriptional Responses to Environmental Inputs
Authors:Luca Giorgetti  Trevor Siggers  Guido Tiana  Greta Caprara  Samuele Notarbartolo  Teresa Corona  Manolis Pasparakis  Paolo Milani  Martha L. Bulyk  Gioacchino Natoli
Affiliation:1. Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, 20139 Milan, Italy;2. Division of Genetics, Department of Medicine, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA 02115, USA;3. INFN, Universita'' di Milano, 20133 Milan, Italy;4. Dipartimento di Fisica, Universita'' di Milano, 20133 Milan, Italy;5. CIMAINA, Universita'' di Milano, 20133 Milan, Italy;6. Institute for Genetics, University of Cologne, 50674 Cologne, Germany;7. Department of Pathology, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA 02115, USA;8. Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA
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