Prospects of using magnetic nanoparticles to potentiate the anticarcinogenic action of dinitrosyl iron complexes with thiol ligands

Low-molecular dinitrosyl iron complexes with thiol-containing ligands (cysteine or glutathione) have recently been shown to be capable of modulating apoptosis. Being in the intact state, the complexes prevent apoptosis, and when decomposed, they initiate it. The possibility is considered of delivering the complexes to tumor tissues by ferromagnetic nanoparticles driven by an external magnetic field.