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Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids |
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| Authors: | Karina Roxana Gheorghe Marina Korotkova Anca Irinel Catrina Linda Backman Erik af Klint Hans-Erik Claesson Olof R?dmark Per-Johan Jakobsson |
| Institution: | (1) Department of Biosciences and Nutrition, Novum, Karolinska Institute, SE-141 57 Huddinge, Sweden;(2) Department of Medicine, Rheumatology Unit, Karolinska University Hospital and Karolinska Institute, S-171 76 Stockholm, Sweden;(3) Orexo AB, Virdings all? 32 A, SE-751 05 Uppsala, Sweden;(4) Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden;(5) Karolinska Biomic Center, Karolinska University Hospital and Karolinska Institute, S-171 76 Stockholm, Sweden |
| Abstract: | IntroductionIt was previously shown that lipoxygenase (LO) pathways are important in the rheumatoid arthritis (RA) inflammatory process and that synovial fluid from RA patients contains high amounts of leukotrienes. We therefore aimed to investigate the 5-LO and 15-LO-1 expression pattern in RA and ostheoarthritis (OA) synovial tissue and to study the effect of intraarticular glucocorticoid (GC) therapy on enzyme expression. |
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