Association between the tryptophan hydroxylase (TpH) gene polymorphic markers and endogenous psychoses |
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| Authors: | R. V. Efimov A. S. Mavlyudova V. E. Golimbet |
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| Affiliation: | (1) Shanghai Jiaotong University, Bio-X Center, Hao Ran Building, 1954 Hua Shan Road, 200030 Shanghai, People’s Republic of China;(2) Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, 294 Taiyuan Road, 200031 Shanghai, China;(3) NHGG Bio-X Center, Shanghai Jiaotong University, 200030 Shanghai, China; |
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| Abstract: | Tryptophan hydroxylase is one of the key enzymes involved in serotonergic metabolism. In many studies, an association between the TpH gene and human mentality, as well as mental disorders was demonstrated. This study was designed to analyze the association between three TpH gene polymorphisms (A218C, T3792A, and (CT) n (CA) n (CT) n ) and endogenous psychoses. The patients included into investigation were represented by those with manic-depressive psychosis (93 individuals) and those with the schizophrenia spectrum disorders (307 individuals). An association between the A218C polymorphism with the disorders of the schizophrenia spectrum was demonstrated. These findings confirmed the data obtained earlier for other populations. In addition, an association between the (CT) n (CA) n (CT) n microsatellite repeats and bipolar disease was shown for the first time. |
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