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排序方式: 共有70条查询结果,搜索用时 31 毫秒
1.
Receptor-mediated regulation of calcium mobilization and cyclic GMP synthesis in neuroblastoma cells 总被引:3,自引:0,他引:3
In neuroblastoma N1E 115 cells, carbachol, histamine and PGE1 elevated cyclic GMP content and, induced the efflux of preloaded 45Ca2+, the release of membrane-bound Ca2+ measured by fluorescent CTC, and the increase in [Ca2+]i as measured by Quin 2 fluorescence. The time course of the responses, the absolute requirement of extracellular Ca2+, the inhibition by receptor blockers, and the concentration dependency on histamine were all similar between these responses. The observation indicates that the mobilization of Ca2+, especially the increase of [Ca2+]i, may be intimately linked to the synthesis of cyclic GMP in the cells. 相似文献
2.
Microbial degradation of quinoline: Kinetic studies with Comamonas acidovorans DSM 6426 总被引:8,自引:0,他引:8
The microbial degradation of quinoline by Comamonas acidovorans was studied in a laboratory scale stirred tank reactor. In continuous culture experiments using quinoline as a sole source of carbon and nitrogen, it was shown by means of mass balances that quinoline was converted completely to biomass, carbon dioxide, and ammonia. Degradation rates up to 0.7 g/L h were obtained. Measured yield coefficients Y(x/s) for quinoline were about 0.7 g/g, which is in agreement with the theoretical value for complete mineralization. Kinetic constants based on Haldane substrate inhibition were evaluated. The values were mu(max) = 0.48 h(-1), K(i) = 69 mg/L, and K(s) < 1.45 mg/L. (c) 1993 John Wiley & Sons, Inc. 相似文献
3.
Degradation of quinoline by immobilized Comamonas acidovorans in a three-phase airlift reactor 总被引:6,自引:0,他引:6
Quinolie degradation by Comamonas acidovorans was studied in a continuously operated three-phase airlift reactor. Porous glass beads were applied as support matrix for cell imobilization by colonization. Under steady-state conditions (S approximately 0), cell attachment was poor at low dilution rates but imporved considerably with increasing dilution rate. Conversion of quinoline was investigated below and above the washout for suspended culture (D(crit) = mu(max) = 0.42 h(-1)). With immobilized cells the reactor could be operated at D > mu(max), and complete conversion of quinoline was achieved as long as the specific quinoline feed rate D*S(0)/X did not exceed the maximum specific degradation rate (r(S, max)). The biofilm thickness was about 100 mum, and its efficiency was about 54% compared to suspended organisms. If quinoline overloads were supplied to the reactor, quinoline, as overloads were supplied to the reactor, quinoline, as well as its pathway intermediates, appeared in the reactor and conversion was low. Hence, the immobilized microorganisms remained viable and active. They could survive quinoline overloads. If the quinoline feed rate was reduced agains, complete conversion was reestablished. (c) 1995 John Wiley & Sons, Inc. 相似文献
4.
Nigel J. Kilby David L. Griggs Stephanie F. Berry 《Plant Cell, Tissue and Organ Culture》1992,28(3):275-280
Intra-population quinoline alkaloid profiles surveying quinine, quinidine, cinchonine and cinchonidine were determined for each of five populations of Cinchona ledgeriana grown as shoot-culture for 125 days. No significant difference in respect of mean alkaloid content between populations was detected. In contrast, there was considerable between-seedling variation in alkaloid content within each population. When nutrients were delivered to shoot-cultures in droplet form by means of an aerosol spray (as compared to the supply of nutrients direct from agar-or liquid-based reservoirs) alkaloid profile was greatly perturbed; most notable in this respect was a four-fold increase in the production of cinchonidine concomitant with a four-fold decrease in the production of cinchonine. These data are discussed with reference to the optimisation of quinoline alkaloid production by juvenile shoot-cultures of Cinchona ledgeriana. 相似文献
5.
Masaru Enomoto Wataru Kitagawa Yoshiaki Yasutake 《Bioscience, biotechnology, and biochemistry》2013,77(8):1324-1327
The quinoline antibiotics aurachins C, D, and L, and a structurally simplified analog of aurachin C were synthesized from 1-(2-nitrophenyl)butane-1,3-dione via reductive cyclizations of δ-nitro ketone intermediates, with zinc or iron as key steps. The results of antimicrobial tests indicate that the N-hydroxyquinolone nucleus mimics the electron carrier in the respiratory chain more strongly than the quinoline N-oxide nucleus. 相似文献
6.
Setzer WN Vogler B Bates RB Schmidt JM Dicus CW Nakkiew P Haber WA 《Phytochemical analysis : PCA》2003,14(1):54-59
A combination of HPLC-MS and HPLC-NMR techniques has been used to analyse the cytotoxic fractions of the dichloromethane extract of bark of Stauranthus perforatus. Six furanocoumarins (byakangelicol, heraclenin, heraclenol, imperatorin, isopimpinellin and xanthotoxin) and nine quinoline alkaloids (two known compounds, veprisine and 5-hydroxy-1-methyl-2-phenyl-4-quinolone, along with seven novel compounds, stauranthine, 3',4'-dihydroxy-3',4'-dihydroveprisine, 3',4'-dihydroxy-3',4'-dihydrostauranthine, 3',6'-dihydroxy-3',6'-dihydroveprisine, 3',6'-dihydroxy-3',6'-dihydrostauranthine, 6'-hydroxy-3'-ketoveprisine and 6'-hydroxy-3'-ketostauranthine) have been identified in the fractions. 相似文献
7.
Burch JD Farand J Colucci J Sturino C Ducharme Y Friesen RW Lévesque JF Gagné S Wrona M Therien AG Mathieu MC Denis D Vigneault E Xu D Clark P Rowland S Han Y 《Bioorganic & medicinal chemistry letters》2011,21(3):1041-1046
Two new series of EP4 antagonists based on naphthalene/quinoline scaffolds have been identified as part of our on-going efforts to develop treatments for inflammatory pain. One series contains an acidic sulfonylurea pharmacophore, whereas the other is a neutral amide. Both series show subnanomolar intrinsic binding potency towards the EP4 receptor, and excellent selectivity towards other prostanoid receptors. While the amide series generally displays poor pharmacokinetic parameters, the sulfonylureas exhibit greatly improved profile. MF-592, the optimal compound from the sulfonylurea series, has a desirable overall preclinical profile that suggests it is suitable for further development. 相似文献
8.
A.A.Leslie Gunatilaka Sivagnanasundram Surendrakumar Ronald H. Thomson 《Phytochemistry》1984,23(4):929-931
The wood of B. zeylanica (Moraceae) contains a new alkaloid broussonetine, identified as 3,4-bis(8- hydroxyquinolin-4-yl)-γ-butyrolactone. 相似文献
9.
The chloroform and ethyl acetate extracts of the leaves of Teclea natalensis have yielded two furoquinoline alkaloids, 6-[(2,3-epoxy-3-methylbutyl)oxy]-4,7-dimethoxyfuro[2,3-b]quinoline and 4,7-dimethoxy-6-[(3-methyl-2-butenyl)oxy]furo[2,3-b]quinoline, and the known alkaloids 4,7-dimethoxy-8-[(3-methyl-2-butenyl)oxy]furo[2,3-b]quinoline, flindersiamine and dictamnine. 相似文献
10.
David Benito-Garagorri Christina M. Standfest-Hauser Karl Kirchner 《Inorganica chimica acta》2010,363(14):3674-1759
The synthesis of bidentate aminophosphine ligands (PNquin) based on 8-hydroxyquinoline is described. These ligands react with cis-Fe(CO)4Br2 to give selectively octahedral complexes of the type cis,cis-Fe(PNquin)(CO)2Br2. There is only one isomer formed where the two CO and the two bromide ligands adopt a cis configuration. The reaction of [RuCp(CH3CN)3]PF6 with PNquin ligands affords the halfsandwich complexes [RuCp(PNquin)(CH3CN)]PF6 in high isolated yields. Likewise, treatment of [Ru(η6-p-cymene)(μ-Cl)Cl]2 with PNquin in the presence of AgCF3SO3 affords halfsandwich complexes of the type [Ru(η6-p-cymene)(PNquin)Cl]CF3SO3. All ligands and complexes are characterized by NMR and IR spectroscopy. The X-ray structure of representative compounds is reported. In addition, the relative stability of isomeric structures and conformers of Fe(PNquin-Ph)(CO)2Br2 is studied by means of DFT calculations. 相似文献