全文获取类型
收费全文 | 2452篇 |
免费 | 234篇 |
国内免费 | 282篇 |
出版年
2024年 | 3篇 |
2023年 | 61篇 |
2022年 | 74篇 |
2021年 | 186篇 |
2020年 | 114篇 |
2019年 | 167篇 |
2018年 | 141篇 |
2017年 | 94篇 |
2016年 | 134篇 |
2015年 | 148篇 |
2014年 | 178篇 |
2013年 | 203篇 |
2012年 | 241篇 |
2011年 | 212篇 |
2010年 | 130篇 |
2009年 | 101篇 |
2008年 | 131篇 |
2007年 | 121篇 |
2006年 | 103篇 |
2005年 | 78篇 |
2004年 | 69篇 |
2003年 | 63篇 |
2002年 | 53篇 |
2001年 | 27篇 |
2000年 | 31篇 |
1999年 | 26篇 |
1998年 | 10篇 |
1997年 | 11篇 |
1996年 | 9篇 |
1995年 | 7篇 |
1994年 | 8篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 9篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1987年 | 4篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1950年 | 1篇 |
排序方式: 共有2968条查询结果,搜索用时 15 毫秒
1.
2.
Xuan He Abishek Chandrashekar Roland Zahn Frank Wegmann Jingyou Yu Noe B. Mercado Katherine McMahan Amanda J. Martinot Cesar Piedra-Mora Sidney Beecy Sarah Ducat Ronnie Chamanza Sietske Rosendahl Huber Marjolein van Heerden Leslie van der Fits Erica N. Borducchi Michelle Lifton Jinyan Liu Dan H. Barouch 《Cell》2021,184(13):3467-3473.e11
3.
4.
5.
6.
7.
8.
9.
J Regnard P Baudrillard B Salah A T Dinh Xuan L Cabanes A Lockhart 《Journal of applied physiology》1990,68(4):1528-1533
We studied changes in lung volumes and in bronchial response to methacholine chloride (MC) challenge when antishock trousers (AST) were inflated at venous occlusion pressure in healthy subjects in the standing posture, a maneuver known to shift blood toward lung vessels. On inflation of bladders isolated to lower limbs, lung volumes did not change but bronchial response to MC increased, as evidenced by a greater fall in the forced expiratory volume in 1 s (FEV1) at the highest dose of MC used compared with control without AST inflation (delta FEV1 = 0.94 +/- 0.40 vs. 0.66 +/- 0.46 liter, P less than 0.001). Full inflation of AST, i.e., lower limb and abdominal bladder inflated, significantly reduced vital capacity (P less than 0.001), functional residual capacity (P less than 0.01), and FEV1 (P less than 0.01) and enhanced the bronchial response to MC challenge compared with partial AST inflation (delta FEV1 = 1.28 +/- 0.47 liter, P less than 0.05). Because there was no significant reduction of lung volumes on partial AST inflation, the enhanced bronchial response to MC cannot be explained solely by changes in base-line lung volumes. An alternative explanation might be a congestion and/or edema of the airway wall on AST inflation. Therefore, to investigate further the mechanism of the increased bronchial response to MC, we pretreated the subjects with the inhaled alpha 1-adrenergic agonist methoxamine, which has both direct bronchoconstrictor and bronchial vasoconstrictor effects.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
10.
Fenghui Pan Xuan He Jie Feng Wenxia Cui Lei Gao Man Li Haiyan Yang Chun Wang Yun Hu 《Journal of cellular physiology》2019,234(8):14090-14099
Type 2 diabetes (T2D) is a glucose regulation disorder that has significantly enhanced mortality and the global disease burden. The prevalence of T2D has increased worldwide and is higher in the elderly. The function of pancreatic islets decreases with age, which is one important reason for the occurrence of diabetes in the elderly. Recently, peptidome analysis has attracted attention. However, the role of age-related peptides in pancreatic dysfunction has not been investigated extensively. Here, we conducted a comparison of endogenous peptides between pancreas from adult and aging mice by liquid chromatography tandem mass spectrometry (LC-MS/MS). A total of 2,089 peptides originating from 1,280 protein precursors were identified, of which 232 were upregulated and 183 were downregulated in the aging mice (fold change ≥ 2 and p < 0.05), suggesting that the expression of pancreatic peptides in mice varied with age. The molecular weight of most peptides was <3.0 kDa, and the isoelectric point distribution had a bimodal characteristic. Further analysis of cleavage site patterns indicated that proteases cleaved pancreatic proteins according to their rules. Moreover, Gene Ontology and pathway analyses showed that the differentially expressed peptides potentially had specific effects on pancreatic dysfunction. Some differential peptides were located within the domains of precursor proteins that were closely associated with the development of diabetes. We believe that our research may advance the current understanding of pancreas-derived peptides and that certain peptides may be involved in the etiology of diabetes. 相似文献