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1.
Nicole Guthrie Andrew Bradlyn Sharon K. Thompson Sophia Yen Jana Haritatos Fred Dillon Steve W. Cole 《PloS one》2015,10(5)
Most adolescents do not achieve the recommended levels of moderate-to-vigorous physical activity (MVPA), placing them at increased risk for a diverse array of chronic diseases in adulthood. There is a great need for scalable and effective interventions that can increase MVPA in adolescents. Here we report the results of a measurement validation study and a preliminary proof-of-concept experiment testing the impact of Zamzee, an accelerometer-linked online intervention system that combines proximal performance feedback and incentive motivation features to promote MVPA. In a calibration study that parametrically varied levels of physical activity in 31 12-14 year-old children, the Zamzee activity meter was shown to provide a valid measure of MVPA (sensitivity in detecting MVPA = 85.9%, specificity = 97.5%, and r = .94 correspondence with the benchmark RT3 accelerometer system; all p < .0001). In a subsequent randomized controlled multi-site experiment involving 182 middle school-aged children assessed for MVPA over 6 wks, intent-to-treat analyses found that those who received access to the Zamzee intervention had average MVPA levels 54% greater than those of a passive control group (p < 0.0001) and 68% greater than those of an active control group that received access to a commercially available active videogame (p < .0001). Zamzee’s effects on MVPA did not diminish significantly over the course of the 6-wk study period, and were statistically significant in both females and males, and in normal- vs. high-BMI subgroups. These results provide promising initial indications that combining the Zamzee activity meter with online proximal performance feedback and incentive motivation features can positively impact MVPA levels in adolescents. 相似文献
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Background
The Arabidopsis var2 mutant displays a unique green and white/yellow leaf variegation phenotype and lacks VAR2, a chloroplast FtsH metalloprotease. We are characterizing second-site var2 genetic suppressors as means to better understand VAR2 function and to study the regulation of chloroplast biogenesis. 相似文献6.
This mainly methodological paper describes the novel use ofan established EEG-based brain imaging technique (Brain ElectricalActivity Mapping or BEAM) to explore human infant responsesto odours. The aim of this study was to evaluate BEAM as aninvestigative tool in infant olfaction. A small sample of 3-month-oldinfants was tested in a low ambient odour environment. The infants'cortical responses to a number of proprietary baby-food odourswere recorded. Two experimental hypotheses were addressed. Thefirst concerned relative differences in cortical response beforeand during odour presentation. The second hypothesis statedthat differences would be seen between the various odorants.The overall results supported the first hypothesis.
1Present address: School of Psychology, University of Birmingham,Birmingham B15 2TT, UK 相似文献
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Sic L. Chan Steven P. Tammariello Steve Estus Mark P. Mattson 《Journal of neurochemistry》1999,73(2):502-512
Prostate apoptosis response-4 (Par-4) is the product of a gene up-regulated in prostate cancer cells undergoing apoptosis. We now report that Par-4 mRNA and protein levels rapidly and progressively increase 4-24 h following trophic factor withdrawal (TFW) in cultured embryonic rat hippocampal neurons. The increased Par-4 levels follow an increase of reactive oxygen species, and precede mitochondrial membrane depolarization, caspase activation, and nuclear chromatin condensation/fragmentation. Pretreatment of cultures with 17beta-estradiol, vitamin E, and uric acid largely prevented Par-4 induction and cell death following TFW, demonstrating necessary roles for oxidative stress and membrane lipid peroxidation in TFW-induced neuronal apoptosis. Par-4 antisense oligonucleotide treatment blocked Par-4 protein increases and attenuated mitochondrial dysfunction, caspase activation, and cell death following TFW. Collectively, our data identify Par-4 as an early and pivotal player in neuronal apoptosis resulting from TFW and suggest that estrogen and antioxidants may prevent apoptosis, in part, by suppressing Par-4 production. 相似文献
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Frank H. Gleason Steve K. Schmidt Agostina V. Marano 《Extremophiles : life under extreme conditions》2010,14(5):417-425
Zoosporic true fungi are thought to be ubiquitous in many ecosystems, especially in cool, moist soils and freshwater habitats
which are rich in organic matter. However, some of the habitats where these fungi are found may periodically experience extreme
conditions, such as soils in extremely dry, hot and cold climates, acidic and alkaline soils, polluted rivers, anaerobic soil
and water, saline soil and water, periglacial soils, oligotrophic soils, tree canopies and hydrothermal vents. It is clear
that many ecotypes of zoosporic true fungi have indeed adapted to extreme or stressful environmental conditions. This conclusion
is supported by studies in both the field and in the laboratory. Therefore, in our opinion, at least some true zoosporic fungi
can be considered to be extremophiles. 相似文献