全文获取类型
收费全文 | 710篇 |
免费 | 35篇 |
出版年
2021年 | 11篇 |
2020年 | 8篇 |
2019年 | 11篇 |
2018年 | 10篇 |
2017年 | 11篇 |
2016年 | 21篇 |
2015年 | 30篇 |
2014年 | 19篇 |
2013年 | 41篇 |
2012年 | 52篇 |
2011年 | 50篇 |
2010年 | 27篇 |
2009年 | 33篇 |
2008年 | 29篇 |
2007年 | 38篇 |
2006年 | 34篇 |
2005年 | 25篇 |
2004年 | 25篇 |
2003年 | 19篇 |
2002年 | 20篇 |
2001年 | 8篇 |
2000年 | 16篇 |
1998年 | 6篇 |
1997年 | 4篇 |
1992年 | 7篇 |
1991年 | 4篇 |
1990年 | 16篇 |
1989年 | 6篇 |
1988年 | 7篇 |
1987年 | 11篇 |
1986年 | 10篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1979年 | 8篇 |
1978年 | 5篇 |
1977年 | 12篇 |
1976年 | 6篇 |
1975年 | 5篇 |
1974年 | 5篇 |
1973年 | 12篇 |
1972年 | 7篇 |
1971年 | 3篇 |
1970年 | 11篇 |
1969年 | 6篇 |
1968年 | 4篇 |
1967年 | 6篇 |
1966年 | 3篇 |
排序方式: 共有745条查询结果,搜索用时 234 毫秒
1.
2.
3.
4.
5.
6.
Ashok V. Bankar Ameeta R. Kumar Smita S. Zinjarde 《Applied microbiology and biotechnology》2009,84(5):847-865
Yarrowia lipolytica is a fungus that degrades hydrophobic substrates very efficiently. The fungus displays several important characteristics
that have encouraged researchers to study various basic biological and biotechnological applications in detail. Although the
organism has been used as model system for studying dimorphism, salt tolerance, heterologous protein expression, and lipid
accumulation, there are no recent reviews on the environmental and industrial applications of this organism. Included here
are applications in bioremediation of environments contaminated with aliphatic and aromatic compounds, organic pollutants,
2,4,6-trinitrotoluene, and metals. A variety of industrially important recent processes for the synthesis of β-hydroxy butyrate,
l-dopa, and emulsifiers have also been reviewed. Production of unique inherent enzymes (inulinases, α-mannosidases), novel
applications of esterases and lipases, and the use of the fungus for heterologous expression of biotechnologically relevant
products have also been highlighted. The review while entailing a general overview focuses critically on some of the recent
advances on the applications of this yeast. The examples cited here demonstrate the use of wild-type, mutant as well as genetically
manipulated strains of Y. lipolytica for the development of different products, processes, and technologies. This also throws light on how a single organism can
be versatile with respect to its metabolic abilities and how it can be exploited for a variety of purposes. This review will
thus form a base for future developments in this field. 相似文献
7.
8.
9.
10.
Vidya Shivaswamy C. K. Ramakrishna Kurup T. Ramasarma 《Molecular and cellular biochemistry》1993,120(2):141-149
Addition of ferrous sulfate, but not ferric chloride, in micromolar concentrations to rat liver mitochondria induced high rates of consumption of oxygen. The oxygen consumed was several times in excess of the reducing capacity of ferrous-iron (O: Fe ratios 5–8). This occurred in the absence of NADPH or any exogenous oxidizable substrate. The reaction terminated on oxidation of ferrous ions. Malondialdehyde (MDA), measured as thiobarbituric acid-reacting material, was produced indicating peroxidation of lipids. The ratio of O2: MDA was about 4: 1. Pretreatment of mitochondria with ferrous sulfate decreased the rate of oxidation (state 3) with glutamate (+malate) as the substrate by about 40% but caused little damage to energy tranduction process as represented by ratios of ADP: O and respiratory control, as well as calcium-stimulated oxygen uptake and energy-dependent uptake of [45Ca]-calcium. Addition of succinate or ubiquinone decreased ferrous iron-induced lipid peroxidation in intact mitochondria. In frozen-thawed mitochondria, addition of succinate enhanced lipid peroxidation whereas ubiquinone had little effect. These results suggest that ferrous-iron can cause peroxidation of mitochondrial lipids without affecting the energy transduction systems, and that succinate and ubiquinone can offer protection from damage due to such ferrous-iron released from the stores within the cells. 相似文献