全文获取类型
收费全文 | 395篇 |
免费 | 22篇 |
国内免费 | 3篇 |
出版年
2023年 | 3篇 |
2022年 | 2篇 |
2021年 | 10篇 |
2020年 | 8篇 |
2019年 | 9篇 |
2018年 | 5篇 |
2017年 | 8篇 |
2016年 | 14篇 |
2015年 | 11篇 |
2014年 | 15篇 |
2013年 | 38篇 |
2012年 | 28篇 |
2011年 | 28篇 |
2010年 | 11篇 |
2009年 | 15篇 |
2008年 | 18篇 |
2007年 | 26篇 |
2006年 | 9篇 |
2005年 | 15篇 |
2004年 | 13篇 |
2003年 | 8篇 |
2002年 | 7篇 |
2001年 | 8篇 |
2000年 | 11篇 |
1999年 | 8篇 |
1998年 | 4篇 |
1997年 | 5篇 |
1996年 | 10篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 7篇 |
1990年 | 6篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1979年 | 4篇 |
1976年 | 2篇 |
1974年 | 6篇 |
1973年 | 1篇 |
1970年 | 2篇 |
1969年 | 4篇 |
1968年 | 2篇 |
1967年 | 4篇 |
1966年 | 1篇 |
1948年 | 1篇 |
排序方式: 共有420条查询结果,搜索用时 156 毫秒
1.
The title compound, 2-{4-[3-(2,5-dimethylphenyl)-3-methylcyclobutyl]thiazol-2-yl}isoindoline-1,3-dione (C24H22N2O2S), was synthesized and characterized by IR-NMR spectroscopy and single-crystal X-ray diffraction. The compound crystallizes in the monoclinic space group P21/c with a?=?19.7799(13) Å, b?=?6.7473(4) Å, c?=?15.7259(9) Å and β?=?103.416(5)°. In addition, the molecular geometry, vibrational frequencies and gauge including atomic orbital (GIAO) 1H and 13C chemical shift values of the title compound in the ground state have been calculated by using the Hartree-Fock (HF) and density functional method (DFT/B3LYP) with 6–31G(d), 6–31 + G(d,p) and LANL2DZ basis sets, and compared with the experimental data. To determine conformational flexibility, molecular energy profile of the title compound was obtained by semi-empirical (AM1) calculations with respect to two selected degrees of torsional freedom, which were varied from ?180° to +180° in steps of 5°. Besides, molecular electrostatic potential, frontier molecular orbitals (FMO) analysis and thermodynamic properties of the title compound were investigated by theoretical calculations. 相似文献
2.
Local community participation and ex situ conservation has the potential to assist the recovery of the endangered Egyptian tortoise, Testudo kleinmanni. We initiated an in situ community‐based conservation and research program from a captive population of T. kleinmanni. We used a captive population of the Egyptian tortoise to train a member of the local community as a research technician and used his indigenous tracking skills and knowledge of the area to collect activity and dietary data on 28 captive tortoises. We overcame problems with illiteracy by creating a data sheet based on symbols and numbers. This data sheet allowed us to use the indigenous knowledge of various people from the community, and employ them in the future. Our local community approach to data collection, in conjunction with a craft program, made the conservation of the Egyptian tortoise more rewarding to the local community by providing a more sustainable form of income than collecting animals for the pet trade. Our multidimensional approach (local community participation as research technicians, craft program, and trust building) for gaining local support eventually led to the rediscovery of wild Egyptian tortoises in North Sinai, which was significant, as this species was presumed extinct in Egypt. We have now shifted our focus to in situ conservation, using the research and local capacity building template developed from this captive population study. Our template can be used by zoos and conservation organizations with small budgets and collections of native species in natural habitats to create similar captive research programs that can be applied to in situ conservation. Zoo Biol 26:397–406, 2007. © 2007 Wiley‐Liss, Inc. 相似文献
3.
G. M. Din 《BMJ (Clinical research ed.)》1948,1(4544):274-275
4.
5.
Cryomicroscope investigation and thermodynamic modeling of the freezing of unfertilized hamster ova 总被引:1,自引:0,他引:1
Thermodynamic computer modeling was used to predict the freezing response of single-celled unfertilized hamster ova. The cell membrane transport characteristics were investigated, using a microscope diffusion chamber system. The mean osmotically inactive cell volume was determined to be 21.6% of the initial cell volume. An overall mean value of 0.8 +/- 0.1 micron3/micron2.min.atm (= 18 +/- 2.5 micron/sec) was determined for the membrane hydraulic coefficient, Lp. The effect of the extracellular solute concentration on Lp was determined at room temperature (approximately 23 degrees C). A thermodynamic computer model was used to predict the cell response to freezing. The predicted response was compared to the actual volumetric response observed during freezing on a temperature-controlled cryomicroscope conduction stage. The effect of the cooling rate on the nucleation temperature of unprotected ova and protected ova suspended in a 1.5 M DMSO solution was investigated. Overall mean nucleation temperatures of -13 and -57.1 degrees C were observed for unprotected and protected ova, respectively, where the mean nucleation temperature for protected ova was strongly cooling rate dependent. 相似文献
6.
7.
8.
Shabana Vohra Maria Musgaard Luet‐Lok Wong Weihong Zhou Philip C. Biggin 《Protein science : a publication of the Protein Society》2013,22(9):1218-1229
The recent crystal structures of CYP101D2, a cytochrome P450 protein from the oligotrophic bacterium Novosphingobium aromaticivorans DSM12444 revealed that both the native (substrate‐free) and camphor‐soaked forms have open conformations. Furthermore, two other potential camphor‐binding sites were also identified from electron densities in the camphor‐soaked structure, one being located in the access channel and the other in a cavity on the surface near the F‐helix side of the F‐G loop termed the substrate recognition site. These latter sites may be key intermediate positions on the pathway for substrate access to or product egress from the active site. Here, we show via the use of unbiased atomistic molecular dynamics simulations that despite the open conformation of the native and camphor‐bound crystal structures, the underlying dynamics of CYP101D2 appear to be very similar to other CYP proteins. Simulations of the native structure demonstrated that the protein is capable of sampling many different conformational substates. At the same time, simulations with the camphor positioned at various locations within the access channel or recognition site show that movement towards the active site or towards bulk solvent can readily occur on a short timescale, thus confirming many previously reported in silico studies using steered molecular dynamics. The simulations also demonstrate how the fluctuations of an aromatic gate appear to control access to the active site. Finally, comparison of camphor‐bound simulations with the native simulations suggests that the fluctuations can be of similar level and thus are more representative of the conformational selection model rather than induced fit. 相似文献
9.
10.
Cytherella maremensis sp. n., a new ostracod from the Sea of Marmara (Turkey) (Crustacea: Ostracoda)
Cytherella maremensis sp. n., belonging to the family Cytherellidae, is described as new from a hydrothermal vent, located in the west of Marmara Island on the North Anatolian Fault crossing the Sea of Marmara. It was collected from a sediment core 55 m below sea level. Cytherella maremensis sp. n. is clearly separated from closely related species by its shape, length-height ratio and ornamentation. 相似文献