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1.
Nuclear ion channel activity is regulated by actin filaments 总被引:1,自引:0,他引:1
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Hanneke Jansen Alet H. Wijga Salome Scholtens Gerard H. Koppelman Dirkje S. Postma Bert Brunekreef Johan C. de Jongste Henri?tte A. Smit Ronald P. Stolk 《PloS one》2015,10(4)
Objective
HbA1c is associated with cardiovascular risk in persons without diabetes and cardiovascular risk accumulates over the life course. Therefore, insight in factors determining HbA1c from childhood onwards is important. We investigated (lifestyle) determinants of HbA1c at age 12 years and the effects of growth on change in HbA1c and the tracking of HbA1c between the age of 8 and 12 years.Study Design and Methods
Anthropometric measurements were taken and HbA1c levels were assessed in 955 children without diabetes aged around 12 years participating in the PIAMA birth cohort study. In 363 of these children HbA1c was also measured at age 8 years. Data on parents and children were collected prospectively by questionnaires.Results
We found no significant association between known risk factors for diabetes and HbA1c at age 12 years. Mean(SD) change in HbA1c between ages 8 and 12 years was 0.6(0.7) mmol/mol per year (or 0.1(0.1) %/yr). Anthropometric measures at age 8 and their change between age 8 and 12 years were not associated with the change in HbA1c. 68.9% of the children remained in the same quintile or had an HbA1c one quintile higher or lower at age 8 years compared to age 12 years.Conclusion
The lack of association between known risk factors for diabetes and HbA1c suggest that HbA1c in children without diabetes is relatively unaffected by factors associated with glycaemia. HbA1c at age 8 years is by far the most important predictor of HbA1c at age 12. Therefore, the ranking of HbA1c levels appear to be fairly stable over time. 相似文献6.
Yasmeen Hanifa Lilanganee Telisinghe Katherine L. Fielding Justin L. Malden Gavin J. Churchyard Alison D. Grant Salome Charalambous 《PloS one》2015,10(5)
Background
We evaluated the diagnostic accuracy of the urine lipoarabinomannan (LAM) antigen detection assay (Clearview TB-ELISA) to screen for tuberculosis in a South African correctional facility.Methods
Between September 2009 and October 2010, male offenders were screened for tuberculosis (symptoms, chest radiograph, two spot sputum specimens for microscopy and culture), and urine tested for LAM. Sensitivity, specificity and predictive values of LAM were calculated using definite and probable tuberculosis combined as our gold standard.Findings
33/871 (3.8%) participants (26% HIV-positive) had tuberculosis. Amongst HIV-positive vs. HIV-negative offenders the sensitivity and specificity of LAM was 7.1% vs. 0% and 98.5% vs. 99.8% respectively.Conclusion
Urine LAM ELISA has inadequate sensitivity for TB screening in this population. 相似文献7.
FRIZZY PANICLE Drives Supernumerary Spikelets in Bread Wheat 总被引:1,自引:0,他引:1
Oxana Dobrovolskaya Caroline Pont Richard Sibout Petr Martinek Ekaterina Badaeva Florent Murat Audrey Chosson Nobuyoshi Watanabe Elisa Prat Nadine Gautier Véronique Gautier Charles Poncet Yuriy L. Orlov Alexander A. Krasnikov Hélène Bergès Elena Salina Lyudmila Laikova Jerome Salse 《Plant physiology》2015,167(1):189-199
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The probe trinitrobenzene sulphonate (TNBS) was used to selectively label the cell surface of normal and Rous sarcoma virus-transformed BHK fibroblasts. A five-fold increase in the number of TNBS-binding groups exposed on the outer membrane surface after neoplastic transformation was measured. The extra trinitrophenyl (TNP) groups bound by transformed cells were mostly removable by mild trypsinization and no differences were found between the amount of TNP bound by phospholipids in both normal and transformed cells. SDS-acrylamide patterns of TNP-labelled membrane proteins purified from normal and transformed cells showed only minor differences. This led to the conclusion that the increased exposure of TNBS-binding groups was due mainly to different binding properties of membrane proteins towards the probe rather than the appearance of new surface components in transformed cells. 相似文献
10.
Anna F. Feller Oliver M. Selz Matthew D. McGee Joana I. Meier Salome Mwaiko Ole Seehausen 《Ecology and evolution》2020,10(14):7445-7462
The East African cichlid radiations are characterized by repeated and rapid diversification into many distinct species with different ecological specializations and by a history of hybridization events between nonsister species. Such hybridization might provide important fuel for adaptive radiation. Interspecific hybrids can have extreme trait values or novel trait combinations and such transgressive phenotypes may allow some hybrids to explore ecological niches neither of the parental species could tap into. Here, we investigate the potential of second‐generation (F2) hybrids between two generalist cichlid species from Lake Malawi to exploit a resource neither parental species is specialized on: feeding by sifting sand. Some of the F2 hybrids phenotypically resembled fish of species that are specialized on sand sifting. We combined experimental behavioral and morphometric approaches to test whether the F2 hybrids are transgressive in both morphology and behavior related to sand sifting. We then performed a quantitative trait loci (QTL) analysis using RADseq markers to investigate the genetic architecture of morphological and behavioral traits. We show that transgression is present in several morphological traits, that novel trait combinations occur, and we observe transgressive trait values in sand sifting behavior in some of the F2 hybrids. Moreover, we find QTLs for morphology and for sand sifting behavior, suggesting the existence of some loci with moderate to large effects. We demonstrate that hybridization has the potential to rapidly generate novel and ecologically relevant phenotypes that may be suited to a niche neither of the parental species occupies. Interspecific hybridization may thereby contribute to the rapid generation of ecological diversity in cichlid radiations. 相似文献