We have used diffusion and branching process methods to investigate fixation rates, probabilities of survival per generation, and times to fixation of mutant genes under different selection methods incorporating individual and family information. Diffusion approximations fit well to simulated results even for large selection coefficients. Methods that give much weight to family information, such as BLUP evaluation which is widely used in animal breeding, reduce fixation rates of mutant genes because of the reduced effective population sizes. In general, it is observed that even mutants with relatively small heterozygous effects (say 0.1 phenotypic standard deviation) are practically ‘safe’ (i.e. their probability of loss from one generation to the next is smaller than, say, 10%) after just a few generations, typically less than 10. For methods of selection with larger effective size, such as within-family selection, the mutant is ‘safe’ in the population somewhat earlier but eventual fixation takes a longer time. Finally we evaluate the amount by which the use of marker assisted selection reduces the fixation probability of newly arisen mutants. 相似文献
Although a wide array of phonological properties seem to backcopy in reduplication, it is an open question whether reduplicative
templates can backcopy as well. It has been argued that natural languages do not have reduplicative
constructions where the base truncates to match the truncated reduplicant (McCarthy & Prince, 1994; McCarthy & Prince, 1999;
Spaelti, 1997; inter alia). In Guarijio Abbreviated Reduplication (Miller, 1996), however, both copies of the reduplicative
construction truncate, instantiating the pattern that has been claimed not to exist. This paper argues that the Guarijio case
fills this typological gap. Although the data can be given a templatic backcopying analysis, this paper defends a Morphological
Doubling Theory (MDT) analysis using cophonologies (Inkelas & Zoll, 2005). In MDT, Guarijio Abbreviated Reduplication results
from the parallel imposition of a truncating cophonology in each copy of the reduplicative construction. Guarijio Abbreviated
Reduplication is predicted to exist by MDT together with other documented cases of parallel phonological modification in reduplication.
I am grateful to many people for helpful comments and suggestions, including Isabel Barreras Aguilar, Laura Downing, Nicholas
Fleisher, Andrew Garrett, Jason Haugen, Larry Hyman, Yuni Kim, Teresa McFarland, David Mortensen, Mary Paster, Eric Raimy,
and Timothy Thornes as well as the audience of the LSA 2005 Annual Meeting in Oakland. I would like to extend a special thanks
to Alan Yu for his detailed comments and suggestions to latter versions of this paper. I am particularly indebted to Sharon
Inkelas, for her generous advice, feedback, and numerous discussions throughout the development of this paper. I am also grateful
to two anonymous reviewers for their comments and criticisms, and especially to Ingo Plag for his patience and detailed suggestions
as editor. All remaining errors and omissions are mine. This study was made possible by fellowships by CONACYT (Consejo Nacional
de Ciencia y Tecnología, México), the University of California Institute for Mexico and the United States (UCMEXUS) and Fulbright. 相似文献
Thirty components were identified in Lavandula latifolia essential oil (spike oil). One of the compounds, espliegol (δ-terpineol), is a new natural product. 相似文献
Genetic variability and assignment analyses demonstrate that the 60 returning adult salmon to the Tambre River in 2005 were not the product of an incipient wild population, but the result of straying from a neighbouring river. 相似文献
Summary In this paper, a study of the relationship between genetic patterns, obtained by the combination of mtDNA-RFLP and PCR-amplified inter-δ sequence DNA polymorphism analysis, and relevant enological phenotypic data (fermentative power, specific productivity, volatile and total acidity) was carried out on Argentinean Saccharomyces cerevisiae isolates from north Patagonia. The use of a powerful statistical tool, Generalized Procrustes analysis, allowed us to weigh the relationship for each isolate in particular, denoting a good enough degree of agreement between molecular and physiological data for most of the population analysed. The inclusion of a physiological feature, as the killer sensitivity biotype, within identification methods resulted in a higher degree of discrimination among isolates and in better correlation between both characterizations. The combined use of methods based on molecular polymorphisms and killer biotype could be applied so as not to miss any isolate with differential enological properties in selection protocols. 相似文献
Genetic rescue is increasingly considered a promising and underused conservation strategy to reduce inbreeding depression and restore genetic diversity in endangered populations, but the empirical evidence supporting its application is limited to a few generations. Here we discuss on the light of theory the role of inbreeding depression arising from partially recessive deleterious mutations and of genetic purging as main determinants of the medium to long-term success of rescue programs. This role depends on two main predictions: (1) The inbreeding load hidden in populations with a long stable demography increases with the effective population size; and (2) After a population shrinks, purging tends to remove its (partially) recessive deleterious alleles, a process that is slower but more efficient for large populations than for small ones. We also carry out computer simulations to investigate the impact of genetic purging on the medium to long term success of genetic rescue programs. For some scenarios, it is found that hybrid vigor followed by purging will lead to sustained successful rescue. However, there may be specific situations where the recipient population is so small that it cannot purge the inbreeding load introduced by migrants, which would lead to increased fitness inbreeding depression and extinction risk in the medium to long term. In such cases, the risk is expected to be higher if migrants came from a large non-purged population with high inbreeding load, particularly after the accumulation of the stochastic effects ascribed to repeated occasional migration events. Therefore, under the specific deleterious recessive mutation model considered, we conclude that additional caution should be taken in rescue programs. Unless the endangered population harbors some distinctive genetic singularity whose conservation is a main concern, restoration by continuous stable gene flow should be considered, whenever feasible, as it reduces the extinction risk compared to repeated occasional migration and can also allow recolonization events.