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Unnikrishnan Parayil Babu Velukutty Anu Gopinath 《Chemical Speciation and Bioavailability》2013,25(4):153-167
AbstractConcentrations of heavy metals (Cd, Co, Cr, Cu and Fe) in surface sediments and their partitioning behaviour between exchangeable, reducible (Fe-Mn oxide bound) and organic/residual phases of the sediments in a typical backwater system of Kerala, viz. the southern upstream part of Cochin Estuarine System (South India), have been studied. Spatial and temporal variations of trace metals are discussed with special reference to pH, dissolved oxygen, salinity, organic carbon and texture of sediment. Metal concentrations in the tide gated part of the estuary were found to be significantly higher when compared to metal concentrations reported from the unrestricted part of the Cochin estuarine system and also those from many of the unpolluted estuaries worldwide. The higher levels of heavy metals in the study area and their characteristic distribution and partitioning behaviour in the surficial sediments were attributed to the presence of a salinity barrier across the backwater system and also by the massive use of pesticides and chemical fertilizers in the vast area of agricultural land near the backwater system. 相似文献
3.
G. Gopinath A. K. Mahapatra J. C. Bharadwaj R. Banerji D. N. Sharma P. N. Tandon 《Journal of biosciences》1989,14(3):255-260
A feasibility study of neural transplantation in adult rhesus monkey was undertaken. Fresh and preserved neocortex containing
multiplying and maturing neurons obtained from 55–70 gestation days were transplanted into the striatum, cerebellum and cerebral
cortex of adult monkeys. Tissues were preserved for 4 days either at subzero temperature in the freezer compartment of the
ordinary refrigerator in Ringer lactate or incubated in culture medium. While 2 monkeys out of 5 injected with preserved tissue
had successful transplants after 4 months, all the 10 monkeys injected with fresh tissue had no transplants. The size of the
two surviving transplants was small. The neurons in the transplants were mainly in clusters. Many of the cells were immature
and some showed early degenerative changes. Neuronal processes were restricted to the transplants and thus showed lack of
morphological integration with the host tissue. Further studies are in progress to define the nature of the embryonic tissue
of primate which can grow and survive and also the role of neural grafts in functional recovery following experimental lesions
of the brain regions. 相似文献
4.
Naveen Admala Reddy Gopinath Adusumilli Raghu Devanna Rohra G Mayur Saravanan Pichai Sharmila Arujnan 《Indian journal of human genetics》2013,19(4):459-464
INTRODUCTION:
Non-syndromic tooth agenesis is a congenital anomaly with significant medical, psychological, and social ramifications. There is sufficient evidence to hypothesize that locus for this condition can be identified by candidate genes.AIM OF THE STUDY:
The aim of this study was to test whether MSX1 671 T > C gene variant was involved in etiology of non-syndromic tooth agenesis in Raichur patients.MATERIALS AND METHODS:
Blood samples were collected with informed consent from 50 subjects having non-syndromic tooth agenesis and 50 controls. Genomic deoxyribonucleic acid (DNA) was extracted from the blood samples, polymerase chain reaction (PCR) was performed, and restriction fragment length polymorphism (RFLP) was performed for digestion products that were evaluated.RESULTS:
The results showed positive correlation between MSX1671 T > C gene variant and non-syndromic tooth agenesis in Raichur patients.CONCLUSION:
MSX1 671 T > C gene variant may be a good screening marker for non-syndromic tooth agenesis in Raichur patients. 相似文献5.
Neetha John Moka Rajasekhar Katta Mohan Girisha Podila Satya Venkata Narasimha Sharma Puthiya Mundyat Gopinath 《Indian journal of human genetics》2013,19(2):165-170
BACKGROUND:
Mental retardation (MR) is a heterogeneous dysfunction of the central nervous system exhibiting complex phenotypes and has an estimated prevalence of 1-3% in the general population. However, in about 50% of the children diagnosed with any form of intellectual disability or developmental delay the cause goes undetected contributing to idiopathic intellectual disability.MATERIALS AND METHODS:
A total of 122 children with developmental delay/MR were studied to identify the microscopic and submicroscopic chromosome rearrangements by using the conventional cytogenetics and multiplex ligation dependent probe amplification (MLPA) analysis using SALSA MLPA kits from Microbiology Research Centre Holland [MRC] Holland.RESULTS:
All the recruited children were selected for this study, after thorough clinical assessment and metaphases prepared were analyzed by using automated karyotyping system. None was found to have chromosomal abnormality; MLPA analysis was carried out in all subjects and identified in 11 (9%) patients.CONCLUSION:
Karyotype analysis in combination with MLPA assays for submicroscopic micro-deletions may be recommended for children with idiopathic MR. 相似文献6.
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Ramachandran Prakasam Mitsuaki Fujimoto Ryosuke Takii Naoki Hayashida Eiichi Takaki Ke Tan Fangxu Wu Sachiye Inouye Akira Nakai 《FEBS letters》2013
The febrile response is elicited by pyrogenic cytokines including IL-6 in response to microorganism infections and diseases in vertebrates. Mammalian HSF1, which senses elevations in temperature, negatively regulates the response by suppressing pyrogenic cytokine expression. We here showed that HSF3, an avian ortholog of mammalian HSF1, directly binds to and activates IL-6 during heat shock in chicken cells. Other components of the febrile response mechanism, such as IL-1β and ATF3, were also differently regulated in mammalian and chicken cells. These results suggest that the febrile response is exacerbated by a feed-forward circuit composed of the HSF3-IL-6 pathway in birds. 相似文献
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Magdalena Banas Katarzyna Zabieglo Gopinath Kasetty Monika Kapinska-Mrowiecka Julia Borowczyk Justyna Drukala Krzysztof Murzyn Brian A. Zabel Eugene C. Butcher Jens M. Schroeder Artur Schmidtchen Joanna Cichy 《PloS one》2013,8(3)
Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent. Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val66-Pro85, which causes direct bacterial lysis. Therefore, chemerin is an antimicrobial agent in human skin. 相似文献