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William J. Pope 《BMJ (Clinical research ed.)》1923,1(3254):833-834
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Early remains of Helianthus annuus L. unearthed at the San Andrés site in the Gulf Coast region of Tabasco, Mexico, constitute the earliest record of domesticated sunflower. Accelerator mass spectrometry (AMS) age determinations of a large domesticated seed and achene produced dates of 4130 ± 40 years before the present (B.P.) and 4085 ± 50 B.P., respectively. These discoveries challenge the longstanding hypothesis that sunflower was domesticated in eastern North America. Moreover, when considered with other recent discoveries on plant domestication, these data suggest a reconsideration of the idea that the eastern United States was an independent hearth for domestication. 相似文献
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F M Pope K S Cheah A C Nicholls A B Price F G Grosveld 《BMJ (Clinical research ed.)》1984,288(6415):431-434
Broad boned lethal osteogenesis imperfecta is a severely crippling disease of unknown cause. By means of recombinant DNA technology a 300 base pair deletion in an alpha 1(I)-like collagen gene was detected in six patients and four complete parent-child groups including patients with this disease. One from each set of the patients'' clinically unaffected parents also carried the deletion, implying that affected patients were genetic compounds. The study suggests that prenatal diagnosis should be possible with 100% accuracy in subjects without the deletion and with 50% accuracy in those who possess it (who would be either heterozygous--normal, or affected with the disease). 相似文献
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Regulation of natural killer cell activity by macrophages in the rheumatoid joint and peripheral blood 总被引:3,自引:0,他引:3
B Combe R Pope B Darnell W Kincaid N Talal 《Journal of immunology (Baltimore, Md. : 1950)》1984,133(2):709-713
Recently, in another study, we observed that indomethacin, a prostaglandin synthetase inhibitor, significantly increased NK activity in both normal and rheumatoid arthritis (RA) peripheral blood (PB) but not in RA synovial fluid (SF). Because macrophages are a major source of prostaglandins, we examined the effect of macrophage-enriched adherent cells (AC) on NK activity as measured by a 3-hr Cr-release assay with K 562 cells. The removal of AC resulted in increased (p less than 0.01) NK activity in both normal and RA PB. In contrast, the removal of AC from RA SF resulted in a significant decrease (p less than 0.001) of NK activity. By using only nonadherent cells (NAC), NK activity in RA SF and synovial tissue (ST) was significantly reduced when compared to autologous RA PB (p less than 0.001). Enhancement of NK activity of SF NAC by both poly I:C and IL 2 was not dependent on AC. Mixing experiments demonstrated that the addition of synovial AC for 16 hr increased NK activity of synovial NAC to a level similar to that of unseparated mononuclear cells, whereas autologous PB AC suppressed NK activity of PB NAC. PB AC, when added to SF NAC, also increased NK activity. Supernatants from synovial mononuclear cells were stimulatory of synovial NAC NK activity, whereas normal PB mononuclear supernatants were suppressive. These observations document 1) a significant reduction of NAC-mediated NK activity in the rheumatoid joint as compared to PB from the same patient, and 2) that AC modulate NK activity differently in the rheumatoid joint as compared to RA or normal PB. 相似文献
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W F Pope 《Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)》1992,199(3):273-281
Events during oogenesis can affect embryogenesis so dramatically that oocytes can be identified that are progenitors of embryos which would probably die if they remained in the host pig, but would live if appropriately transferred to another female. This review goes backward from embryonic to oocyte development, first discussing how subtle differences between littermate embryos can result in the death of some embryos and then relating the causes of those differences to events during follicular maturation. Embryonic development is not uniform in swine. The larger blastocysts within a litter synthesize estradiol sooner than their less developed contemporaries. Estradiol advances uterine secretions to the benefit of the more developed blastocysts, but results in an asynchronous and hostile environment for the less developed blastocysts. Through a series of experiments, the pattern of oocyte and follicular development was found to be one of the sources of subsequent disparity among blastocysts. In pigs mated before ovulation, the first oocytes released at ovulation were the first fertilized and became the more developed blastocysts 12 days later. Inversely, the later ovulated oocytes were the last to be fertilized and became the smaller blastocysts. These smaller blastocysts can develop normally, but because of estrogenic advancement of uterine secretions, they will preferentially die. 相似文献
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F. M. Pope 《BMJ (Clinical research ed.)》1907,1(2425):1471-1477
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