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Maternal serum alpha-fetoprotein screening activities of state health agencies: a survey. 总被引:5,自引:5,他引:0 下载免费PDF全文
Maternal serum alpha-fetoprotein (MSAFP) screening has been demonstrated to be cost-effective on a population basis and is becoming standard practice. The American Society of Human Genetics has twice published policy statements to define the essential elements of a quality screening program. The present study reviewed the impact of these policy statements on state public-health agencies with respect to regulation or provision of MSAFP screening in their jurisdictions. With a few exceptions, states have not elected to play a major role in provision or regulation of this test. There is need to address issues of funding, standards, and data collection in a collaborative effort, if policy statements on genetic services are to be translated into effective state population screening. 相似文献
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C. W. Cunningham 《Biological invasions》2008,10(1):1-6
The rapid range southward expansion of the periwinkle Littorina littorea from the Canadian maritimes has fueled a long-running debate over whether this species was introduced to North America by
human activity. A reappraisal of the mitochondrial DNA sequence evidence finds considerable endemic allelic diversity in the
American population. The degree of endemic genetic diversity is higher than expected from human-mediated colonization, but
not so much to suggest that it survived the last glacial maximum in America. Coalescent estimates of population divergence
agree that colonization of America preceded European contact. A reappraisal of the ITS nuclear sequence data finds extensive
recombination. Taking this recombination into account strengthens the genetic case against human-mediated introduction. Finally,
a reappraisal of conflicting allozyme studies from the 1970’s supports a claim of limited divergence between American and
European populations. This is consistent with post-glacial colonization, but the allozyme data cannot distinguish between
natural or human-mediated colonization. Taken as a whole, the DNA sequence data supports the many sub-fossil reports of an
American L. littorea population in the Canadian maritimes that preceded even the first visits by the Vikings. 相似文献
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