全文获取类型
收费全文 | 392篇 |
免费 | 20篇 |
出版年
2021年 | 3篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 7篇 |
2015年 | 13篇 |
2014年 | 6篇 |
2013年 | 8篇 |
2012年 | 20篇 |
2011年 | 21篇 |
2010年 | 25篇 |
2009年 | 8篇 |
2008年 | 17篇 |
2007年 | 10篇 |
2006年 | 12篇 |
2005年 | 13篇 |
2004年 | 16篇 |
2003年 | 14篇 |
2002年 | 15篇 |
2001年 | 14篇 |
2000年 | 15篇 |
1999年 | 9篇 |
1998年 | 5篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 7篇 |
1990年 | 3篇 |
1989年 | 6篇 |
1988年 | 9篇 |
1987年 | 3篇 |
1986年 | 8篇 |
1985年 | 6篇 |
1984年 | 9篇 |
1983年 | 3篇 |
1982年 | 7篇 |
1981年 | 9篇 |
1980年 | 10篇 |
1979年 | 12篇 |
1978年 | 8篇 |
1977年 | 8篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1974年 | 3篇 |
1973年 | 5篇 |
1971年 | 2篇 |
1968年 | 2篇 |
1966年 | 2篇 |
1959年 | 1篇 |
1958年 | 1篇 |
1957年 | 1篇 |
排序方式: 共有412条查询结果,搜索用时 140 毫秒
1.
2.
3.
4.
We show that, in 1862, Richard Burton collected the type specimen of Pan troglodytes vellerosus not on Mount Cameroon, as has been generally assumed, but in Gabon. Therefore, P. t. vellerosus is not the correct name for the chimpanzee population of western Cameroon and southern Nigeria, if that population is taxonomically
distinct. As First Reviser, we choose the name Pan troglodytes ellioti for this population of chimpanzees, based on Anthropopithecus
ellioti named by Matschie [Matschie P (1914) Neue Affen aus Mittelafrika. Sitzungsber Ges Naturforsch Freunde Berlin 1914:323–342] from a specimen in the Humboldt Museum,
Berlin, collected in Bascho (=Basho), Cameroon, and given to the museum in 1905. 相似文献
5.
The neural fat-body sheath surrounding the abdominal ventral nerve cord of Carausius morosus has been examined by light and electron microscopy. A perineural chamber between the ventral nerve cord and the sheath is present in the ganglionic regions, but in the interconnective regions the sheath directly covers the neural lamella. The sheath is differentiated into secretory cells with abundant granular endoplasmic reticulum and many mitochondria and storage cells with lipid droplets and granules presumed to be glycogen. The whole sheath is pervaded with tracheoblast cells and associated tracheal and tracheolar tubules. Recent evidence suggests that this sheath may have little power of ionic regulation. The function of the sheath, deduced from the fine structure described here, appears to be to serve the nutritional needs of the central nervous system. Why a sheath of this type appears to be confined to herbivorous insects with unusual haemolymph cationic balance is still unexplained. 相似文献
6.
William E. Serafin John A. Oates Walter C. Hubbard 《Prostaglandins & other lipid mediators》1984,27(6):899-911
Five milligrams of [5,6,8,9,11,12,14,15-3H8]-leukotriene B4 (LTB4) (1.68 Ci/mmol) were infused into a monkey over a three hour period. Twenty-five per cent of the infused 3H-activity was recovered in the urine during the twenty hours of collection. Plasma and urinary metabolite volatility studies revealed that in contrast to previously studied eicosanoids, more than 70% per cent of the infused LTB43H-label was converted to tritiated water. The major nonvolatile urinary metabolite of LTB4 representing 0.8% of the infused material was identified as 20-OH-LTB4. LTB4 was not excreted in the urine. Other nonvolatile metabolites of LTB4 representing less than 0.4% each of the infused material were isolated from the urine. While there was an adequate quantity of some of these metabolites for partial characterization, there was insufficient material for structural elucidation. Further studies were performed in rabbits in which either LTB4 or the structurally related compound 8,15-dihydroxyeicosatetraenoic acid (8,15-diHETE) were infused intravenously. In these rabbits the metabolism of LTB4 and 8,15-diHETE was similar to that in the monkey with greater than 80% of the infused 3H-activity converted to tritiated water. These studies suggest that leukotriene B4 and structurally related compounds undergo extensive degradation in vivo via the β-oxidation system. 相似文献
7.
David S. Duncan Lawrence G. Oates Ilya Gelfand Neville Millar G. Philip Robertson Randall D. Jackson 《Global Change Biology Bioenergy》2019,11(2):416-426
Nitrous oxide (N2O) is a potent greenhouse gas and major component of the net global warming potential of bioenergy feedstock cropping systems. Numerous environmental factors influence soil N2O production, making direct correlation difficult to any one factor of N2O fluxes under field conditions. We instead employed quantile regression to evaluate whether soil temperature, water‐filled pore space (WFPS), and concentrations of soil nitrate () and ammonium () determined upper bounds for soil N2O flux magnitudes. We collected data over 6 years from a range of bioenergy feedstock cropping systems including no‐till grain crops, perennial warm‐season grasses, hybrid poplar, and polycultures of tallgrass prairie species each with and without nitrogen (N) addition grown at two sites. The upper bounds for soil N2O fluxes had a significant and positive correlation with all four environmental factors, although relatively large fluxes were still possible at minimal values for nearly all factors. The correlation with was generally weaker, suggesting it is less important than in driving large fluxes. Quantile regression slopes were generally lower for unfertilized perennials than for other systems, but this may have resulted from a perpetual state of nitrogen limitation, which prevented other factors from being clear constraints. This framework suggests efforts to reduce concentrations of in the soil may be effective at reducing high‐intensity periods—”hot moments”—of N2O production. 相似文献
8.
Irene Zagol-Ikapite Iberia R. Sosa Denise Oram Audra Judd Kalyani Amarnath Venkataraman Amarnath Donald Stec John A. Oates Olivier Boutaud 《Journal of lipid research》2015,56(11):2196-2205
The thromboxane synthase converts prostaglandin H2 to thromboxane A2 and malondialdehyde (MDA) in approximately equimolar amounts. A reactive dicarbonyl, MDA forms covalent adducts of amino groups, including the ε-amine of lysine, but the importance of this reaction in platelets was unknown. Utilizing a novel LC/MS/MS method for analysis of one of the MDA adducts, the dilysyl-MDA cross-link, we demonstrated that dilysyl-MDA cross-links in human platelets are formed following platelet activation via the cyclooxygenase (COX)-1/thromboxane synthase pathway. Salicylamine and analogs of salicylamine were shown to react with MDA preferentially, thereby preventing formation of lysine adducts. Dilysyl-MDA cross-links were measured in two diseases known to be associated with increased platelet activation. Levels of platelet dilysyl-MDA cross-links were increased by 2-fold in metabolic syndrome relative to healthy subjects, and by 1.9-fold in sickle cell disease (SCD). In patients with SCD, the reduction of platelet dilysyl-MDA cross-links following administration of nonsteroidal anti-inflammatory drug provided evidence that MDA modifications of platelet proteins in this disease are derived from the COX pathway. In summary, MDA adducts of platelet proteins that cross-link lysines are formed on platelet activation and are increased in diseases associated with platelet activation. These protein modifications can be prevented by salicylamine-related scavengers. 相似文献
9.
Paulo FP Pimenta Alessandra S Orfano Ana C Bahia Ana PM Duarte Claudia M Ríos-Velásquez Fabrício F Melo Felipe AC Pessoa Giselle A Oliveira Keillen MM Campos Luis Martínez Villegas Nilton Barnabé Rodrigues Rafael Nacif-Pimenta Rejane C Sim?es Wuelton M Monteiro Rogerio Amino Yara M Traub-Cseko José BP Lima Maria GV Barbosa Marcus VG Lacerda Wanderli P Tadei Nágila FC Secundino 《Memórias do Instituto Oswaldo Cruz》2015,110(1):23-47
In the Americas, areas with a high risk of malaria transmission are mainly located in
the Amazon Forest, which extends across nine countries. One keystone step to
understanding the Plasmodium life cycle in Anopheles species from the Amazon Region
is to obtain experimentally infected mosquito vectors. Several attempts to colonise
Ano- pheles species have been conducted, but with only short-lived success or no
success at all. In this review, we review the literature on malaria transmission from
the perspective of its Amazon vectors. Currently, it is possible to develop
experimental Plasmodium vivax infection of the colonised and field-captured vectors
in laboratories located close to Amazonian endemic areas. We are also reviewing
studies related to the immune response to P. vivax infection of Anopheles aquasalis,
a coastal mosquito species. Finally, we discuss the importance of the modulation of
Plasmodium infection by the vector microbiota and also consider the anopheline
genomes. The establishment of experimental mosquito infections with Plasmodium
falciparum, Plasmodium yoelii and Plasmodium berghei parasites that could provide
interesting models for studying malaria in the Amazonian scenario is important.
Understanding the molecular mechanisms involved in the development of the parasites
in New World vectors is crucial in order to better determine the interaction process
and vectorial competence. 相似文献
10.
Maria C Anholeti Rodrigo C Duprat Maria R Figueiredo Maria AC Kaplan Marcelo Guerra Santos Marcelo S Gonzalez Norman A Ratcliffe Denise Feder Selma R Paiva Cicero B Mello 《Memórias do Instituto Oswaldo Cruz》2015,110(5):629-635
Studies evaluated the effects of hexanic extracts from the fruits and flowers
ofClusia fluminensis and the main component of the flower
extract, a purified benzophenone (clusianone), against Aedes
aegypti. The treatment of larvae with the crude fruit or flower extracts
from C. fluminensis did not affect the survival ofAe.
aegypti (50 mg/L), however, the flower extracts significantly delayed
development of Ae. aegypti. In contrast, the clusianone (50 mg/L) isolate from the
flower extract, representing 54.85% of this sample composition, showed a highly
significant inhibition of survival, killing 93.3% of the larvae and completely
blocking development of Ae. aegypti. The results showed, for the first time, high
activity of clusianone against Ae. aegypti that both killed and inhibited mosquito
development. Therefore, clusianone has potential for development as a biopesticide
for controlling insect vectors of tropical diseases. Future work will elucidate the
mode of action of clusianone isolated from C. fluminensis. 相似文献