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排序方式: 共有1819条查询结果,搜索用时 171 毫秒
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Samuel García Myriam Liz Juan J Gómez-Reino Carmen Conde 《Arthritis research & therapy》2010,12(1):R33
Introduction
Synovial hyperplasia is a main feature of rheumatoid arthritis pathology that leads to cartilage and bone damage in the inflamed joints. Impaired apoptosis of resident synoviocytes is pivotal in this process. Apoptosis resistance seems to involve defects in the extrinsic and intrinsic apoptotic pathways. The aim of this study was to investigate the association of PI3Kinase/Akt and the mitochondrial apoptotic pathway in the resistance of rheumatoid arthritis (RA) fibroblast like synovial cells (FLS) to Fas-mediated apoptosis. 相似文献4.
Myriam R. Hirt Marlee Tucker Thomas Müller Benjamin Rosenbaum Ulrich Brose 《Ecology and evolution》2020,10(14):7094-7105
- Realized trophic niches of predators are often characterized along a one‐dimensional range in predator–prey body mass ratios. This prey range is constrained by an “energy limit” and a “subdue limit” toward small and large prey, respectively. Besides these body mass ratios, maximum speed is an additional key component in most predator–prey interactions.
- Here, we extend the concept of a one‐dimensional prey range to a two‐dimensional prey space by incorporating a hump‐shaped speed‐body mass relation. This new “speed limit” additionally constrains trophic niches of predators toward fast prey.
- To test this concept of two‐dimensional prey spaces for different hunting strategies (pursuit, group, and ambush predation), we synthesized data on 63 terrestrial mammalian predator–prey interactions, their body masses, and maximum speeds.
- We found that pursuit predators hunt smaller and slower prey, whereas group hunters focus on larger but mostly slower prey and ambushers are more flexible. Group hunters and ambushers have evolved different strategies to occupy a similar trophic niche that avoids competition with pursuit predators. Moreover, our concept suggests energetic optima of these hunting strategies along a body mass axis and thereby provides mechanistic explanations for why there are no small group hunters (referred to as “micro‐lions”) or mega‐carnivores (referred to as “mega‐cheetahs”).
- Our results demonstrate that advancing the concept of prey ranges to prey spaces by adding the new dimension of speed will foster a new and mechanistic understanding of predator trophic niches and improve our predictions of predator–prey interactions, food web structure, and ecosystem functions.
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Christopher S. Carlson Shelley Force Aldred Philip K. Lee Russell P. Tracy Stephen M. Schwartz Mark Rieder Kiang Liu O. Dale Williams Carlos Iribarren E. Cora Lewis Myriam Fornage Eric Boerwinkle Myron Gross Cashell Jaquish Deborah A. Nickerson Richard M. Myers David S. Siscovick Alexander P. Reiner 《American journal of human genetics》2008,82(1):251
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Myriam Baes 《Cell biochemistry and biophysics》2000,32(1-3):229-237
The gene knockout technology has been applied to generate mice lacking functional peroxisomes. These mice are a model for
Zellweger syndrome and other peroxisome biogenesis disorders that are lethal in early life. Extensive biochemical, ultrastructural,
and neurodevelopmental analyses indicate that the peroxisome deficient mice closely mimic the pathology in Zellweger patients
and will be a very useful tool to elucidate the pathogenesis of this disease. 相似文献
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Luciane M.R. Neto Maristela H. Andraus Myriam C. Salvadori 《Journal of chromatography. B, Analytical technologies in the biomedical and life sciences》1996,678(2):211
A method is described for the qualiitative and quantitative determination of phenylbutazone and oxyphenbutazone in horse urine and plasma samples viewing antidoping control. A horse was administered intravenously with 3 g of phenylbutazone. For the qualitative determination, a screening by HPLC was performed after acidic extraction of the urine samples and the confirmation process was realized by GC-MS. Using the proposed method it was possible to detect phenylbutazone and oxyphenbutazone in urine for up to 48 and 120 h, respectively. For the quantitation of these drugs the plasma was deproteinized with acetonitrile and 20 gml were injected directly into the HPLC system equipped with a UV detector and LiChrospher RP-18 column. The mobile phase used was 0.01 M acetic acid in methanol (45:55, v/v). The limit of detection was 0.5 μg/ml for phenylbutazone and oxyphenbutazone and the limit of quantitation was 1.0 μg/ml for both drugs. Using the proposed method it was possible to quantify phenylbutazone up to 30 h and oxyphenbutazone up to 39 h after administration. 相似文献
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Brian W Wong Elke Marsch Lucas Treps Myriam Baes Peter Carmeliet 《The EMBO journal》2017,36(15):2187-2203
In contrast to the general belief, endothelial cell (EC) metabolism has recently been identified as a driver rather than a bystander effect of angiogenesis in health and disease. Indeed, different EC subtypes present with distinct metabolic properties, which determine their function in angiogenesis upon growth factor stimulation. One of the main stimulators of angiogenesis is hypoxia, frequently observed in disease settings such as cancer and atherosclerosis. It has long been established that hypoxic signalling and metabolism changes are highly interlinked. In this review, we will provide an overview of the literature and recent findings on hypoxia‐driven EC function and metabolism in health and disease. We summarize evidence on metabolic crosstalk between different hypoxic cell types with ECs and suggest new metabolic targets. 相似文献
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