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目的探讨骨形成蛋白(BMPs)与口腔鳞癌的发生、发展的可能关系。方法将含有BMP-Ⅱ突变受体的真核表达载体转染入Tea8113舌癌细胞,筛选和鉴定后,构建稳定表达BMP-Ⅱ突变受体的细胞株tBRⅡ-Tea8113。对tBRⅡ—Tca8113细胞和Tca8113细胞分别进行MTT检测,流式细胞仪(FCM)分析、BrdU标记检测细胞的增殖活性及DNA合成;检测tBRⅡ-Tca8113细胞和Tea8113细胞的凋亡及细胞周期相关因子(CyclinD1,CDK-4,p27,p57)的表达。结果Tea8113细胞和tBRⅡ-Tea8113细胞的增殖指数MTT检测为0.47±0.01和0.35±0.008(t=22.953,P=0.000),BrdU检测为12.0±3.4和23.0±1.9(f=6.918,P=0.000),FCM检测为6.3和7.9;两组的凋亡指数为3.7±1.2和8.7±1.6(t=29.583,P=0.000);细胞周期因子在Tca8113和tBRⅡ-ca8113细胞中的平均灰度测量值为CyclinD1(186.5±2.4和145.6±3.9,t=28.244,P=0.000),CDK4(169.9±2.9和129.5±3.2,t=29.583,P=0.000),p27(110.1±1.1和167.34-1.8,f=85.754,P=0.000),p57(107.9±2.1和156.8±2.2,t=50.844,P=0.000)。结论BMPs及其受体可能在口腔上皮组织的恶变过程中有重要作用,研究结果为探讨BMPs信号在上皮性肿瘤中的作用提供了重要依据。tBRⅡ-Tea8113细胞的建立,进一步表明了BMPs及其受体在口腔上皮组织的恶变过程中有重要作用,并为进一步探讨BMP信号在上皮性肿瘤的恶变过程中的作用奠定了基础。 相似文献
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Mathieu Nacher Celia Basurko Antoine Adenis Emilie Gaubert-Marechal Emilie Mosnier Sophie Edouard Vincent Vantilcke Sindou Sivapregassam Benoit Tressières André Cabié Pierre Couppié 《PloS one》2013,8(11)
A retrospective cohort study was conducted on 1541 HIV-infected patients to determine variables associated with the incidence of herpes zoster. A single failure Cox model showed that herpes zoster incidence increased following the first 6 months of antiretroviral treatment adjusted hazard ratio (AHR)=5 (95%CI=2.6-9.2), P<0.001; in the >60 years age group AHR=2 (95%CI=1-4), P=0.04; in patients in the top CD8 quartile AHR=2.1 (95%CI=1.3-3.6), P<0.001; and in patients previously reported to use crack cocaine AHR=5.9, (95%CI=1.4-25), P=0.02. Herpes zoster incidence increased in patients with CD4 counts<500 per mm3 and gradually declined since 1992-1996, with AHR=0.3 (95%CI=0.2-0.5), P<0.001 for the 1997-2002 period and AHR=0.24 (95%CI=0.14-0.4), P<0.001 for the 2002-2008 period. Contrary to what has been described elsewhere, there was no specific effect of protease inhibitors on herpes zoster incidence. The present study is the first to suggest that crack cocaine is associated with an increased incidence of herpes zoster. The neurological or immunological effects of crack are discussed. 相似文献
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Abstract: A mass occurrence, numbering tens of thousands of individuals in a single lens, belonging to a single species of asteroid, is described from the late Maastrichtian (Late Cetaceous) of Morocco. The lens of partially silicified asteroidal limestone is made up largely of fully articulated specimens of similar size and probably represents the mass mortality of a single recruitment. By comparison with mass strandings of the present‐day species Asterias rubens (Linnaeus), it can be inferred that a feeding swarm of individuals was swept into a submarine channel by either a storm or an exceptionally strong tidal current, and permanently buried. The genus and species are herein described as Cretasterias reticulatus gen. et sp. nov. The exceptional preservation of the material enables the identification of wreath organs (clusters of crossed pedicellariae set in a dermal pad around spines) for the first time in the fossil record. Comparison between extant Asteriidae, putative fossil asteriids and C. reticulatus provides ambiguous evidence of its affinities; it appears to display a combination of plesiomorphic and derived characters. It is shown that all Mesozoic forcipulatid asteroids described so far share a very simple arm construction (single row of adradial ossicles) unknown in adult extant Forcipulatida. 相似文献
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