全文获取类型
收费全文 | 1935篇 |
免费 | 284篇 |
出版年
2018年 | 21篇 |
2016年 | 22篇 |
2015年 | 40篇 |
2014年 | 32篇 |
2013年 | 41篇 |
2012年 | 58篇 |
2011年 | 64篇 |
2010年 | 41篇 |
2009年 | 34篇 |
2008年 | 52篇 |
2007年 | 55篇 |
2006年 | 59篇 |
2005年 | 43篇 |
2004年 | 52篇 |
2003年 | 59篇 |
2002年 | 50篇 |
2001年 | 39篇 |
2000年 | 54篇 |
1999年 | 45篇 |
1998年 | 24篇 |
1996年 | 21篇 |
1995年 | 30篇 |
1994年 | 31篇 |
1993年 | 30篇 |
1992年 | 33篇 |
1991年 | 37篇 |
1990年 | 36篇 |
1989年 | 40篇 |
1988年 | 27篇 |
1987年 | 36篇 |
1986年 | 32篇 |
1985年 | 35篇 |
1984年 | 26篇 |
1983年 | 37篇 |
1982年 | 28篇 |
1981年 | 34篇 |
1980年 | 31篇 |
1979年 | 38篇 |
1978年 | 39篇 |
1977年 | 30篇 |
1976年 | 25篇 |
1975年 | 21篇 |
1974年 | 38篇 |
1973年 | 38篇 |
1972年 | 22篇 |
1971年 | 26篇 |
1970年 | 24篇 |
1967年 | 19篇 |
1966年 | 19篇 |
1963年 | 19篇 |
排序方式: 共有2219条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
Brian A. Davies Leslie O. Morton John R. Jefferson Cody N. Rozeveld Luke C. Doskey Nicholas F. LaRusso David J. Katzmann 《Molecular biology of the cell》2020,31(22):2463
Intercellular communication is critical for organismal homeostasis, and defects can contribute to human disease states. Polarized epithelial cells execute distinct signaling agendas via apical and basolateral surfaces to communicate with different cell types. Small extracellular vesicles (sEVs), including exosomes and small microvesicles, represent an understudied form of intercellular communication in polarized cells. Human cholangiocytes, epithelial cells lining bile ducts, were cultured as polarized epithelia in a Transwell system as a model with which to study polarized sEV communication. Characterization of isolated apically and basolaterally released EVs revealed enrichment in sEVs. However, differences in apical and basolateral sEV composition and numbers were observed. Genetic or pharmacological perturbation of cellular machinery involved in the biogenesis of intralumenal vesicles at endosomes (the source of exosomes) revealed general and domain-specific effects on sEV biogenesis/release. Additionally, analyses of signaling revealed distinct profiles of activation depending on sEV population, target cell, and the function of the endosomal sorting complex required for transport (ESCRT)-associated factor ALG-2–interacting protein X (ALIX) within the donor cells. These results support the conclusion that polarized cholangiocytes release distinct sEV pools to mediate communication via their apical and basolateral domains and suggest that defective ESCRT function may contribute to disease states through altered sEV signaling. 相似文献
7.
J. J. Brown R. H. Chinn R. Fraser A. F. Lever J. J. Morton J. I. S. Robertson M. Tree M. A. Waite D. M. Park 《BMJ (Clinical research ed.)》1973,1(5854):650-654
A patient with recurrent weakness and blurring of consciousness associated with hyperkalaemia due to aldosterone deficiency is reported. The plasma concentrations of renin, angiotensin II, and aldosterone were low and did not increase during sodium deprivation. Blood angiotensin I was also low while renin-substrate concentration was normal. Infusion of angiotensin produced a distinct rise in plasma aldosterone. The patient was treated successfully with fludrocortisol.The results support the concept that the renin-angiotensin system is an important regulator of aldosterone secretion and that in the syndrome of acquired selective hypoaldosteronism the primary abnormality may be a deficiency of renin. It is suggested that a selective lack of aldosterone should be considered in all cases of otherwise unexplained hyperkalaemia. 相似文献
8.
Morton Smart 《BMJ (Clinical research ed.)》1945,2(4425):581-582
9.
10.
ARM-BEARING MICROTUBULES ASSOCIATED WITH AN UNUSUAL DESMOSOME-LIKE JUNCTION 总被引:1,自引:1,他引:0 下载免费PDF全文
Morton H. Friedman 《The Journal of cell biology》1971,49(3):916-920