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The ergosterol and lecithin absorption IR-spectra were studied in a nonpolar anhydrous medium. The thermodynamical and spectral characteristics of dimeric associates and the enthalpy value for trimeric associates of this sterol are determined. Thermodynamical and spectral parameters of ergosterol intermolecular associates with lecithin in a nonpolar anhydrous medium are found. It is established that the intermolecular interaction of lecithin with ergosterol occurs according to the mechanism of hydrogen bond. A conclusion is drawn that the presence of binary bonds and methyl groups in the cyclic and aliphatic parts of the sterol molecule affects greatly the structure of the model membrane and its strength. It is shown that under conditions of the experiment the oxygen of the phosphate group contributes to formation of the molecular associates of lecithin with sterols and not that of the carbonyl group. The obtained experimental data may be at use when studying structural disturbances of native membranes in norm and with different pathologies. 相似文献
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Cation binding effects on the pH, thermal and urea denaturation transitions in alpha-lactalbumin 总被引:4,自引:0,他引:4
The binding of monovalent (Na+, K+) and divalent (Ca2+, Mg2+) cations to bovine alpha-lactalbumin at 20 and 37 degrees C has been studied by means of intrinsic protein fluorescence. The values of apparent binding constants for these ions obtained at 37 degrees C are about one order of magnitude lower than those measured at 20 degrees C. Urea and alkali (pH greater than 10) induce unfolding transitions which involve stable partially unfolded intermediates for all metal ion-bound forms of alpha-lactalbumin. Heating induces similar partially unfolded states. Nevertheless, the partially unfolded states induced by heating, urea, alkaline or acidic treatments are somewhat different in their tryptophan residue environment properties. The results have been interpreted in terms of a simple scheme of equilibria between metal-free and metal-bound forms in their native, partially unfolded and unfolded states. The scheme provides an approach to the quantitative interpretation of any transition equilibrium shift induced by a low molecular mass species able to be bound by a protein. 相似文献
5.
Individual and age-related characteristics of visual perception as a whole and its individual components were studied in seven-year-old children as related to their brain functional development. A dependence was found between the success of visual perception and the characteristics determining the functional maturity of both the cerebral cortex and the brain regulatory structures. Difficulties in noise resistance, visuospatial perception, and visual analysis/synthesis were greater in first-year school students with signs of immaturity of the bioelectrical activity of the cerebral cortex. Poor development of the visual perception system in schoolchildren was also determined by an underdeveloped frontothalamic regulatory system and deviations in the functional state of the nonspecific activation system. 相似文献
6.
N. G. Morozova M. A. Maslov V. V. Myagchenkov G. A. Serebrennikova 《Russian Journal of Bioorganic Chemistry》2010,36(5):657-662
An approach to the synthesis of cationic carbohydrate surfactants with potential antimicrobial and transfecting activities
is proposed. 相似文献
7.
R. Yu. Kiselyova M. A. Myagkova I. V. Shakir E. A. Bryun V. S. Morozova 《Applied Biochemistry and Microbiology》2011,47(7):707-710
Enzyme-linked immunosorbent assay (ELISA) for detection of amphetamines in urine was developed. The conditions for ELISA using
an antigen obtained from the derivative of amphetamine and ovalbumin were optimized. It was shown that the specificity of
the proposed method when used in clinical conditions corresponds to that of gas chromatography with mass spectrometric detection. 相似文献
8.
A Iu Baryshnikov R M Radzikhovskaia L F Morozova E G Slavina N I Belianchikova 《Biulleten' eksperimental'no? biologii i meditsiny》1977,83(6):719-721
The immune antimyeloblast serum (AMS) was obtained from horses immunized with white blood cells from patients suffering from chronic myeloid leukemia (CML) at the blast crisis stage; the serum was completely absorbed with normal red blood cells and white blood cells (WBC). The absorbed antiserum remained cytotoxic to blast cells from 20 of 42 patients with CML at the blast crisis stage. AMS failed to react with the WBC from patients with CML in its chronic phase, and from patients with other types of leukemia Morphological studies indicated a possibility of identification of the antigen associated with myeloblasts from the blood of patients with CML blast crisis, by means to AMS. 相似文献
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