全文获取类型
收费全文 | 10327篇 |
免费 | 982篇 |
国内免费 | 726篇 |
出版年
2023年 | 85篇 |
2022年 | 128篇 |
2021年 | 333篇 |
2020年 | 296篇 |
2019年 | 385篇 |
2018年 | 366篇 |
2017年 | 314篇 |
2016年 | 458篇 |
2015年 | 615篇 |
2014年 | 769篇 |
2013年 | 788篇 |
2012年 | 932篇 |
2011年 | 850篇 |
2010年 | 603篇 |
2009年 | 546篇 |
2008年 | 669篇 |
2007年 | 592篇 |
2006年 | 521篇 |
2005年 | 446篇 |
2004年 | 439篇 |
2003年 | 380篇 |
2002年 | 381篇 |
2001年 | 130篇 |
2000年 | 133篇 |
1999年 | 134篇 |
1998年 | 100篇 |
1997年 | 98篇 |
1996年 | 65篇 |
1995年 | 49篇 |
1994年 | 41篇 |
1993年 | 32篇 |
1992年 | 54篇 |
1991年 | 48篇 |
1990年 | 25篇 |
1989年 | 23篇 |
1988年 | 15篇 |
1987年 | 26篇 |
1986年 | 8篇 |
1985年 | 17篇 |
1984年 | 16篇 |
1983年 | 7篇 |
1980年 | 6篇 |
1979年 | 10篇 |
1977年 | 6篇 |
1974年 | 7篇 |
1970年 | 7篇 |
1968年 | 11篇 |
1967年 | 7篇 |
1966年 | 7篇 |
1964年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
1.
2.
Jianhua Zhang Mei Liu Hongjian Jin Liandong Deng Jinfeng Xing Anjie Dong 《AAPS PharmSciTech》2010,11(2):894-903
Lactate esters are widely used as food additives, perfume materials, medicine additives, and personal care products. The objective
of this work was to investigate the effect of a series of lactate esters as penetration enhancers on the in vitro skin permeation of four drugs with different physicochemical properties, including ibuprofen, salicylic acid, dexamethasone
and 5-fluorouracil. The saturated donor solutions of the evaluated drugs in propylene glycol were used in order to keep a
constant driving force with maximum thermodynamic activity. The permeability coefficient (K
p), skin concentration of drugs (SC), and lag time (T), as well as the enhancement ratios for K
p and SC were recorded. All results indicated that lactate esters can exert a significant influence on the transdermal delivery
of the model drugs and there is a structure-activity relationship between the tested lactate esters and their enhancement
effects. The results also suggested that the lactate esters with the chain length of fatty alcohol moieties of 10–12 are more
effective enhancers. Furthermore, the enhancement effect of lactate esters increases with a decrease of the drug lipophilicity,
which suggests that they may be more efficient at enhancing the penetration of hydrophilic drugs than lipophilic drugs. The
influence of the concentration of lactate esters was evaluated and the optimal concentration is in the range of 5∼10 wt.%.
In sum, lactate esters as a penetration enhancer for some drugs are of interest for transdermal administration when the safety
of penetration enhancers is a prime consideration. 相似文献
3.
4.
Michael D. Jensen Ji?í Bajnárek Sang Yeoup Lee Soren Nielsen Christina Koutsari 《Journal of lipid research》2009,50(9):1863-1869
The relationship between overnight postabsorptive (fasting) respiratory exchange ratio (RER) and plasma FFA concentrations was addressed using data from three separate protocols, each of which involved careful control of the antecedent diet. Protocol 1 examined the relationship between fasting RER and the previous daytime RER. In Protocol 2 fasting, RER and plasma palmitate concentrations were measured in 29 women and 31 men (body mass index <30 kg·m−2). Protocol 3 analyzed data from Nielsen et al. (Nielsen, S., Z. K. Guo, J. B. Albu, S. Klein, P. C. O''Brien, M. D. Jensen. 2003. Energy expenditure, sex and endogenous fuel availability in humans. J. Clin. Invest. 111: 981-988.) to understand how fasting RER and palmitate concentrations relate within individuals during four consecutive measurements. The results were as follows: 1) Fasting RER was correlated (r = 0.74, P < 0.001) with the previous day''s average RER, and less so with RER variability. 2) Fasting RER was correlated (r = −0.39, P = 0.007) with fasting plasma palmitate concentrations. 3) The pattern of the RER/palmitate relationship was similar within individuals and between individuals; a negative slope was observed significantly more often than a positive slope (χ2 test; P < 0.001). Our findings suggest that, despite a fixed food quotient, the slight departures from energy equilibrium in a controlled General Clinical Research Center environment can effect plasma FFA concentrations. We suggest that including indirect calorimetry as part of FFA metabolism studies may aid in data interpretation. 相似文献
5.
Tyrosinase plays a pivotal role in the synthesis of melanin pigment synthesis on skin utilizing tyrosine as a substrate. Melanin is responsible for the protection against harmful ultraviolet irradiation, which can cause significant pathological conditions, such as skin cancers. However, it can also create esthetic problems when accumulated as hyperpigmented spots. Various skin-whitening ingredients which inhibit tyrosinase activity have been identified. Some of them, especially ones with natural product origins, possess phenolic moiety and have been employed in cosmetic products. Semi-synthetic and synthetic inhibitors have also been developed under inspiration of the natural inhibitors yet some of which have no phenolic groups. In this review, tyrosinase inhibitors with natural, semi-synthetic and synthetic origins are listed up with their structures, activities and characteristics. Further, a recent report on the adverse effect of a natural melanin synthesis inhibitor which was included in skin-whitening cosmetics is also briefly discussed. 相似文献
6.
7.
Scaffolding proteins are involved in the incorporation, anchoring, maintenance, and removal of AMPA receptors (AMPARs) at synapses, either through a direct interaction with AMPARs or via indirect association through auxiliary subunits of transmembrane AMPAR regulatory proteins (TARPs). Synaptic scaffolding molecule (S-SCAM) is a newly characterized member of the scaffolding proteins critical for the regulation and maintenance of AMPAR levels at synapses, and directly binds to TARPs through a PDZ interaction. However, the functional significance of S-SCAM–TARP interaction in the regulation of AMPARs has not been tested. Here we show that overexpression of the C-terminal peptide of TARP-γ2 fused to EGFP abolished the S-SCAM-mediated enhancement of surface GluA2 expression. Conversely, the deletion of the PDZ-5 domain of S-SCAM that binds TARPs greatly attenuated the S-SCAM-induced increase of surface GluA2 expression. In contrast, the deletion of the guanylate kinase domain of S-SCAM did not show a significant effect on the regulation of AMPARs. Together, these results suggest that S-SCAM is regulating AMPARs through TARPs. 相似文献
8.
9.
10.