全文获取类型
收费全文 | 110927篇 |
免费 | 1800篇 |
国内免费 | 1802篇 |
出版年
2023年 | 203篇 |
2022年 | 252篇 |
2021年 | 844篇 |
2020年 | 600篇 |
2019年 | 737篇 |
2018年 | 12450篇 |
2017年 | 11043篇 |
2016年 | 8195篇 |
2015年 | 1722篇 |
2014年 | 1575篇 |
2013年 | 1743篇 |
2012年 | 5905篇 |
2011年 | 14214篇 |
2010年 | 12847篇 |
2009年 | 8977篇 |
2008年 | 10763篇 |
2007年 | 12211篇 |
2006年 | 1066篇 |
2005年 | 1223篇 |
2004年 | 1535篇 |
2003年 | 1555篇 |
2002年 | 1244篇 |
2001年 | 609篇 |
2000年 | 452篇 |
1999年 | 308篇 |
1998年 | 178篇 |
1997年 | 155篇 |
1996年 | 108篇 |
1995年 | 111篇 |
1994年 | 84篇 |
1993年 | 99篇 |
1992年 | 116篇 |
1991年 | 133篇 |
1990年 | 94篇 |
1989年 | 75篇 |
1988年 | 73篇 |
1987年 | 66篇 |
1986年 | 39篇 |
1985年 | 44篇 |
1984年 | 30篇 |
1983年 | 40篇 |
1982年 | 23篇 |
1979年 | 20篇 |
1978年 | 16篇 |
1977年 | 19篇 |
1976年 | 15篇 |
1975年 | 19篇 |
1972年 | 261篇 |
1971年 | 280篇 |
1962年 | 27篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Jakub Horák 《Journal of Insect Conservation》2017,21(1):1-5
Insect and veteran trees are important parts of ecosystems and are usually included in ecological studies of forest management. The loss of veteran trees in woodlands and open landscapes would lead to the loss of saproxylic organisms—an important part of biodiversity. Hence, the persistence of many specialized insects depends on the presence of veteran trees scattered in woodlands (e.g. ancient wood pastures, game parks or protected areas), cities, towns and villages (e.g. avenues, parks or chateau parks) or open landscapes (e.g. fishpond dams, solitary trees or fruit orchards). Veteran tree conditions could be fairly well described by three components—diameter, age and microhabitats present. The problem is that diameter belongs to the most studied characteristics, while age and microhabitats, which can be quite complicated to measure, are much less studied. This paper illustrates that, due to this unbalanced use of indicators of veteran-tree conditions, we are still missing some important information on saproxylic species ecology—and sometimes only large trees might be studied, rather than real veterans. Although we already know that veteran trees are essential habitat for a range of saproxylic organisms, there are still gaps in our knowledge of the specific conditions that veteran trees provide. It is vital that these are quantified and understood so that this information can be used to conserve veteran trees and their associated species. 相似文献
2.
Single Cell Transcriptome Amplification with MALBAC 总被引:1,自引:0,他引:1
3.
4.
A common problem that is encountered in medical applications is the overall homogeneity of survival distributions when two survival curves cross each other. A survey demonstrated that under this condition, which was an obvious violation of the assumption of proportional hazard rates, the log-rank test was still used in 70% of studies. Several statistical methods have been proposed to solve this problem. However, in many applications, it is difficult to specify the types of survival differences and choose an appropriate method prior to analysis. Thus, we conducted an extensive series of Monte Carlo simulations to investigate the power and type I error rate of these procedures under various patterns of crossing survival curves with different censoring rates and distribution parameters. Our objective was to evaluate the strengths and weaknesses of tests in different situations and for various censoring rates and to recommend an appropriate test that will not fail for a wide range of applications. Simulation studies demonstrated that adaptive Neyman’s smooth tests and the two-stage procedure offer higher power and greater stability than other methods when the survival distributions cross at early, middle or late times. Even for proportional hazards, both methods maintain acceptable power compared with the log-rank test. In terms of the type I error rate, Renyi and Cramér—von Mises tests are relatively conservative, whereas the statistics of the Lin-Xu test exhibit apparent inflation as the censoring rate increases. Other tests produce results close to the nominal 0.05 level. In conclusion, adaptive Neyman’s smooth tests and the two-stage procedure are found to be the most stable and feasible approaches for a variety of situations and censoring rates. Therefore, they are applicable to a wider spectrum of alternatives compared with other tests. 相似文献
5.
6.
7.
Haiye Luan Baojian Guo Yuhan Pan Chao Lv Huiquan Shen Rugen Xu 《Plant Growth Regulation》2018,85(3):399-409
Waterlogging is one of the major stresses limiting crop production worldwide. The understanding of the mechanisms of plant adaptations to waterlogging stress helps improve plant tolerance to stress. In this study, physiological responses and morpho-anatomical adaptations of seven different barley genotypes were investigated under waterlogging stress. The results showed that the waterlogging-tolerant varieties (TX9425, Yerong, TF58) showed less reduction in plant height, SPAD (soil–plant analyses development analyses) value, tillers, shoot and root biomasses than did the waterlogging-sensitive varieties (Franklin, Naso Nijo, TF57). Under waterlogging stress condition, the tolerant genotypes also showed a much larger number of adventitious roots than did the sensitive genotypes. More intercellular spaces and better integrated chloroplast membrane structures were observed in the leaves of the waterlogging-tolerant cultivars, which is likely due to increased ethylene content, decreased ABA content and less accumulation of O2.?. The ability to form new adventitious roots and intercellular spaces in shoots can also be used as selection criteria in breeding barley for waterlogging tolerance. 相似文献
8.
Roles of Peroxisome Proliferator-Activated Receptor Gamma on Brain and Peripheral Inflammation 总被引:1,自引:0,他引:1
Sonia Villapol 《Cellular and molecular neurobiology》2018,38(1):121-132
Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is expressed in diverse cell types, including vessels, immune and glial cells, and neurons. PPARγ plays crucial roles in the regulation of cellular differentiation, lipid metabolism, or glucose homeostasis. PPARγ ligands also exert effects on attenuating degenerative processes in the brain, as well as in peripheral systems, and it has been associated with the control of anti-inflammatory mechanisms, oxidative stress, neuronal death, neurogenesis, differentiation, and angiogenesis. This review will highlight key advances in the understanding of the PPARγ-related mechanisms responsible for neuroprotection after brain injuries, both ischemia and traumatic brain injury, and it will also cover the natural and synthetic agonist for PPARγ, angiotensin receptor blockers, and PPARγ antagonists, used in experimental and clinical research. A better understanding of the pleiotropic mechanisms and applications of these drugs to improve the recovery and to repair the acute and chronic induced neuroinflammation after brain injuries will pave the way for more effective therapeutic strategies after brain deficits. 相似文献
9.
Exposure to nicotine is known to cause adverse effects in many target organs including kidney. Epidemiological studies suggest that nicotine-induced kidney diseases are prevalent worldwide. However, the impact of duration of exposure on the nicotine-induced adverse effects in normal kidney cells and the underlying molecular mechanism is still unclear. Hence, the objective of this study was to evaluate both acute and long-term effects of nicotine in normal human kidney epithelial cells (HK-2). Cells were treated with 1 and 10 µM nicotine for acute and long-term duration. The result of cell viability showed that the acute exposure to 1 µM nicotine has no significant effect on growth. However, the 10 µM nicotine caused significant decrease in the growth of HK-2 cells. The long-term exposure resulted in significantly increased cell growth in both 1 and 10 µM nicotine-treated groups. Analysis of cell cycle and expression of marker genes related to proliferation and apoptosis further confirmed the effects of nicotine. Additionally, the analysis of growth signaling pathway revealed the decreased level of pAKT in cells with acute exposure whereas the increased level of pAKT in long-term nicotine-exposed cells. This suggests that nicotine, through modulating the AKT pathway, controls the duration-dependent effects on the growth of HK-2 cells. In summary, this is the first report showing long-duration exposure to nicotine causes increased proliferation of human kidney epithelial cells through activation of AKT pathway. 相似文献
10.