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1.
Effects of roads and land use on frog distributions across spatial scales and regions in the Eastern and Central United States 下载免费PDF全文
David M. Marsh Bradley J. Cosentino Kara S. Jones Joseph J. Apodaca Karen H. Beard Jane Margaret Bell Christine Bozarth Derrick Carper Julie F. Charbonnier Andreia Dantas Elizabeth A. Forys Miran Foster Jaquelyn General Kristen S. Genet Macie Hanneken Kyle R. Hess Shane A. Hill Faisal Iqbal Nancy E. Karraker Eran S. Kilpatrick Tom A. Langen James Langford Kathryn Lauer Alison J. McCarthy Joseph Neale Saumya Patel Austin Patton Cherie Southwick Nathaniel Stearrett Nicholas Steijn Mohammad Tasleem Joseph M. Taylor James R. Vonesh 《Diversity & distributions》2017,23(2):158-170
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Peter G. Walley Gemma Hough Jonathan D. Moore John Carder Marian Elliott Andrew Mead Julie Jones Graham Teakle Guy Barker Vicky Buchanan-Wollaston Paul Hand David Pink Rosemary Collier 《Molecular breeding : new strategies in plant improvement》2017,37(1):4
Domesticated lettuce varieties encompass much morphological variation across a range of crop type groups, with large collections of cultivars and landrace accessions maintained in genebanks. Additional variation not captured during domestication, present in ancestral wild relatives, represents a potentially rich source of alleles that can deliver to sustainable crop production. However, these large collections are difficult and costly to screen for many agronomically important traits. In this paper, we describe the generation of a diversity collection of 96 lettuce and wild species accessions that are amenable to routine phenotypic analysis and their genotypic characterization with a panel of 682 newly developed expressed sequence tag (EST)-linked KASP? single nucleotide polymorphism (SNP) markers that are anchored to the draft Lactuca sativa genome assembly. To exemplify the utility of these resources, we screened the collection for putative sources of resistance to currant-lettuce aphid (Nasonovia ribisnigri) and carried out association analyses to look for potential SNPs linked to resistance. 相似文献
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Julie A. Eclov Qingwen Qian Rebecca Redetzke Quanhai Chen Steven C. Wu Chastity L. Healy Steven B. Ortmeier Erin Harmon Gregory C. Shearer Timothy D. O’Connell 《Journal of lipid research》2015,56(12):2297-2308
Heart failure with preserved ejection fraction (HFpEF) is half of all HF, but standard HF therapies are ineffective. Diastolic dysfunction, often secondary to interstitial fibrosis, is common in HFpEF. Previously, we found that supra-physiologic levels of ω3-PUFAs produced by 12 weeks of ω3-dietary supplementation prevented fibrosis and contractile dysfunction following pressure overload [transverse aortic constriction (TAC)], a model that resembles aspects of remodeling in HFpEF. This raised several questions regarding ω3-concentration-dependent cardioprotection, the specific role of EPA and DHA, and the relationship between prevention of fibrosis and contractile dysfunction. To achieve more clinically relevant ω3-levels and test individual ω3-PUFAs, we shortened the ω3-diet regimen and used EPA- and DHA-specific diets to examine remodeling following TAC. The shorter diet regimen produced ω3-PUFA levels closer to Western clinics. Further, EPA, but not DHA, prevented fibrosis following TAC. However, neither ω3-PUFA prevented contractile dysfunction, perhaps due to reduced uptake of ω3-PUFA. Interestingly, EPA did not accumulate in cardiac fibroblasts. However, FFA receptor 4, a G protein-coupled receptor for ω3-PUFAs, was sufficient and required to block transforming growth factor β1-fibrotic signaling in cultured cardiac fibroblasts, suggesting a novel mechanism for EPA. In summary, EPA-mediated prevention of fibrosis could represent a novel therapy for HFpEF. 相似文献
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Ronald B. Walter Julie Harless Rita T. Svensson Klaus D. Kallman Donald C. Morizot Rodney S. Nairn 《Genomics》1991,10(4)
Fish gene mapping studies have identified several syntenic groups showing conservation over more than 400 million years of vertebrate evolution. In particular, Xiphophorus linkage group IV has been identified as a homolog of human chromosomes 15 and 19. During mammalian evolution, loci coding for glucosephosphate isomerase, peptidase D, muscle creatine kinase, and several DNA repair genes (ERCC1, ERCC2, and XRCC1) appear as a conserved syntenic group on human chromosome 19. When X. clemenciae and X. milleri PstI endonuclease-digested genomic DNA was used in Southern analysis with a human ERCC2 DNA repair gene probe, a strongly cross-hybridizing restriction fragment length polymorphism was observed. Backcrosses to X. clemenciae from X. milleri × X. clemenciae F1 hybrids allowed tests for linkage of the ERCC2-like polymorphism to markers covering a large proportion of the genome. Statistically significant evidence for linkage was found only for ERCC2L1 and CKM (muscle creatine kinase), with a total of 41 parents and 2 recombinants (4.7% recombination, χ2 = 35.37, P < 0.001); no evidence for linkage to GPI and PEPD in linkage group IV was detected. The human chromosome 19 synteny of ERCC2 and CKM thus appears to be conserved in Xiphophorus, while other genes located nearby on human chromosome 19 are in a separate linkage group in this fish. If Xiphophorus gene arrangements prove to be primitive, human chromosome 19 may have arisen from chromosome fusion or translocation events at some point since divergence of mammals and fishes from a common ancestor. 相似文献