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Maurice J. van Eis JeanPierre Evenou Walter Schuler Gerhard Zenke Eric Vangrevelinghe Juergen Wagner Peter von Matt 《Bioorganic & medicinal chemistry letters》2017,27(4):781-786
The indolyl-naphthyl maleimide 7 is a potent inhibitor of the classical PKC isotypes α,β and shows excellent selectivity over the novel PKC isotypes δ,ε,η,θ and other kinases belonging to the AGC family. The SAR around 7 as well as the physico-chemical characteristics of selected derivatives and their activity in T and B cell activation and proliferation assays are discussed. 相似文献
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Christine Chabrolle Eric JeanPierre Lucie Tosca Christelle Ramé Joëlle Dupont 《Reproductive biology and endocrinology : RB&E》2008,6(1):11
Background
Reproductive dysfunction in the diabetic female rat is associated with altered folliculogenesis and steroidogenesis. However, the molecular mechanisms involved in the reduction of steroid production have not been described. Adiponectin is an adipocytokine that has insulin-sensitizing actions including stimulation of glucose uptake in muscle and suppression of glucose production in liver. Adiponectin acts via two receptor isoforms – AdipoR1 and AdipoR2 – that are regulated by hyperglycaemia and hyperinsulinaemia in liver and muscle. We have recently identified AdipoR1 and AdipoR2 in rat ovary. However, their regulation in ovaries of diabetic female rat remains to be elucidated. 相似文献
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