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Erhard Hinz 《Cell and tissue research》1959,49(3):339-343
Ohne Zusammenfassung 相似文献
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Hartmut Seliger Michael Hinz Sigalit Gura Boa Nitzan Shlomo Margel 《Nucleosides, nucleotides & nucleic acids》2013,32(6-7):1305-1307
Abstract The use of composite beads consisting of a 6 μm polystyrene core with 30 nm surface-bound silica particles to routine automatic oligodeoxynucleotide (ODN) synthesis is described. 相似文献
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Cao Yong Hinz Leon Taylor Christopher A. Metzke Brian Cummings Kevin S. 《Hydrobiologia》2022,849(9):2193-2208
Hydrobiologia - Fish hosts are critical for freshwater mussels. However, correlation between mussel and fish species richness (SR) is variable. Here, we examine how the environment affects this... 相似文献
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Mohamad Wessam Alnouri Stephan Jepards Alessandro Casari Anke C. Schiedel Sonja Hinz Christa E. Müller 《Purinergic signalling》2015,11(3):389-407
Adenosine receptors (ARs) have emerged as new drug targets. The majority of data on affinity/potency and selectivity of AR ligands described in the literature has been obtained for the human species. However, preclinical studies are mostly performed in mouse or rat, and standard AR agonists and antagonists are frequently used for studies in rodents without knowing their selectivity in the investigated species. In the present study, we selected a set of frequently used standard AR ligands, 8 agonists and 16 antagonists, and investigated them in radioligand binding studies at all four AR subtypes, A1, A2A, A2B, and A3, of three species, human, rat, and mouse. Recommended, selective agonists include CCPA (for A1AR of rat and mouse), CGS-21680 (for A2A AR of rat), and Cl-IB-MECA (for A3AR of all three species). The functionally selective partial A2B agonist BAY60-6583 was found to additionally bind to A1 and A3AR and act as an antagonist at both receptor subtypes. The antagonists PSB-36 (A1), preladenant (A2A), and PSB-603 (A2B) displayed high selectivity in all three investigated species. MRS-1523 acts as a selective A3AR antagonist in human and rat, but is only moderately selective in mouse. The comprehensive data presented herein provide a solid basis for selecting suitable AR ligands for biological studies.
Electronic supplementary material
The online version of this article (doi:10.1007/s11302-015-9460-9) contains supplementary material, which is available to authorized users. 相似文献10.
Andrew Frederick Johnson Giulia Gorelli Stuart Rees Jenkins Jan Geert Hiddink Hilmar Hinz 《Proceedings. Biological sciences / The Royal Society》2015,282(1799)
The effects of bottom trawling on benthic invertebrates include reductions of biomass, diversity and body size. These changes may negatively affect prey availability for demersal fishes, potentially leading to reduced food intake, body condition and yield of fishes in chronically trawled areas. Here, the effect of trawling on the prey availability and diet of two commercially important flatfish species, plaice (Pleuronectes platessa) and dab (Limanda limanda), was investigated over a trawling intensity gradient in the Irish Sea. Previous work in this area has shown that trawling negatively affects the condition of plaice but not of dab. This study showed that reductions in local prey availability did not result in reduced feeding of fish. As trawling frequency increased, both fish and prey biomass declined, such that the ratio of fish to prey remained unchanged. Consequently, even at frequently trawled sites with low prey biomass, both plaice and dab maintained constant levels of stomach fullness and gut energy contents. However, dietary shifts in plaice towards energy-poor prey items were evident when prey species were analysed individually. This, together with a potential decrease in foraging efficiency due to low prey densities, was seen as the most plausible cause for the reduced body condition observed. Understanding the relationship between trawling, benthic impacts, fish foraging and resultant body condition is an important step in designing successful mitigation measures for future management strategies in bottom trawl fisheries. 相似文献