全文获取类型
收费全文 | 1461篇 |
免费 | 127篇 |
出版年
2023年 | 4篇 |
2021年 | 16篇 |
2020年 | 10篇 |
2019年 | 12篇 |
2018年 | 17篇 |
2017年 | 26篇 |
2016年 | 30篇 |
2015年 | 62篇 |
2014年 | 56篇 |
2013年 | 78篇 |
2012年 | 100篇 |
2011年 | 96篇 |
2010年 | 61篇 |
2009年 | 65篇 |
2008年 | 68篇 |
2007年 | 88篇 |
2006年 | 82篇 |
2005年 | 87篇 |
2004年 | 66篇 |
2003年 | 82篇 |
2002年 | 70篇 |
2001年 | 17篇 |
2000年 | 19篇 |
1999年 | 24篇 |
1998年 | 30篇 |
1997年 | 16篇 |
1996年 | 18篇 |
1995年 | 25篇 |
1994年 | 24篇 |
1993年 | 24篇 |
1992年 | 22篇 |
1991年 | 14篇 |
1990年 | 18篇 |
1989年 | 25篇 |
1988年 | 10篇 |
1987年 | 13篇 |
1986年 | 19篇 |
1985年 | 13篇 |
1984年 | 12篇 |
1983年 | 9篇 |
1982年 | 4篇 |
1981年 | 7篇 |
1980年 | 8篇 |
1979年 | 6篇 |
1978年 | 11篇 |
1977年 | 10篇 |
1976年 | 4篇 |
1974年 | 3篇 |
1972年 | 2篇 |
1970年 | 3篇 |
排序方式: 共有1588条查询结果,搜索用时 15 毫秒
1.
Herman van der Kooij Ron Jacobs Bart Koopman Henk Grootenboer 《Biological cybernetics》1999,80(5):299-308
A model is presented to study and quantify the contribution of all available sensory information to human standing based
on optimal estimation theory. In the model, delayed sensory information is integrated in such a way that a best estimate of
body orientation is obtained. The model approach agrees with the present theory of the goal of human balance control. The
model is not based on purely inverted pendulum body dynamics, but rather on a three-link segment model of a standing human
on a movable support base. In addition, the model is non-linear and explicitly addresses the problem of multisensory integration
and neural time delays. A predictive element is included in the controller to compensate for time delays, necessary to maintain
erect body orientation. Model results of sensory perturbations on total body sway closely resemble experimental results. Despite
internal and external perturbations, the controller is able to stabilise the model of an inherently unstable standing human
with neural time delays of 100 ms. It is concluded, that the model is capable of studying and quantifying multisensory integration
in human stance control. We aim to apply the model in (1) the design and development of prostheses and orthoses and (2) the
diagnosis of neurological balance disorders.
Received: 25 August 1997 / Accepted in revised form: 8 December 1998 相似文献
2.
Henk J Busscher 《Biofouling》2013,29(2-4):361-362
BIOFILMS II PROCESS ANALYSIS AND APPLICATIONS. Edited by James D Bryers. Wiley Liss Incorporated, New York, 2000; 432 pp; US$ 139; ISBN 0–471–29656–2 相似文献
3.
Hein Stam Henk W. van Verseveld Wytske de Vries Adriaan H. Stouthamer 《FEMS microbiology letters》1986,35(2-3):215-220
Abstract The effect of carbon starvation on growth and poly-β-hydroxybutyrate (PHB) utilization in oxygen-limited chemostat cultures of Rhizobium ORS571 was studied. Under oxygen-limited growth conditions PHB was not degraded. When in a nitrogen-fixing oxygen-limited culture, after stopping the medium supply, the dissolved oxygen concentration was maintained at 10 μM, a slow breakdown of PHB was observed. Addition of ammonia and air to a nitrogen-fixing oxygen-limited culture after the medium supply had been stopped, resulted in the simultaneous utilization of PHB and succinate. The possible use of the energy derived from PHB degradation in Rhizobia bacteria and bacteroids is discussed. 相似文献
4.
5.
Mechanisms of multidrug transporters 总被引:11,自引:0,他引:11
6.
Salivation to food cues is typically explained in terms of mere stimulus-response links. However, food cues seem to especially increase salivation when food is attractive, suggesting a more complex psychological process. Adopting a grounded cognition perspective, we suggest that perceiving a food triggers simulations of consuming it, especially when attractive. These simulations then induce salivation, which effectively prepares the body for eating the food. In two experiments, we systematically examined the role of simulations on salivation to food cues. As stimuli, both experiments used an attractive, a neutral, and a sour food, as well as a non-food control object. In Experiment 1, participants were instructed to simulate eating every object they would be exposed to. We then exposed them to each object separately. Salivation was assessed by having participants spit their saliva into a cup after one minute of exposure. In Experiment 2, we instructed half of participants to simulate eating each object, and half to merely look at them, while measuring salivation as in Experiment 1. Afterwards, participants rated their simulations and desire to eat for each object separately. As predicted, foods increased salivation compared to the non-food control object, especially when they were attractive or sour (Exp. 1 and 2). Importantly, attractive and sour foods especially increased salivation when instructed to simulate (Exp. 2). These findings suggest that consumption simulations play an important role in inducing salivary responses to food cues. We discuss directions for future research as well as the role of simulations for other appetitive processes. 相似文献
7.
Frank Rasche Ester Marco-Noales Henk Velvis Leo S. van Overbeek María M. López Jan D. van Elsas Angela Sessitsch 《Plant and Soil》2006,289(1-2):123-140
Genetically modified potatoes expressing antibacterial protein T4 lysozyme may offer effective control strategies for bacterial pathogens causing severe potato diseases. Apart from this beneficial effect, it is very important to investigate such engineered potatoes carefully for potential adverse effects on potato-associated bacteria which frequently exhibit plant beneficial functions such as plant growth promotion and antagonism towards pathogens invading the plant. Two field experiments were carried out in Spain to analyze the potential effects of conventional and genetically modified T4-lysozyme producing potatoes on shoot-associated bacteria. The first baseline field trial 2002 was performed in Meliana in which three conventional potato lines, Achirana Inta, Desirée, and Merkur, were cultivated and sampled at flowering. The second field trial was conducted in Cella in 2003 in order to compare the effects of a senescent transgenic, T4 lysozyme expressing potato trait, Desirée DL 12, with its isogenic, non-transformed parental line Desirée. Structural characteristics of potato shoot-associated bacteria was assayed by 16S rRNA-based terminal restriction fragment length polymorphism (T-RFLP) analysis and dominant community members within T-RFLP profiles were identified by sequence analysis of generated 16S rRNA gene libraries. Cultivable bacteria isolated from shoots of potatoes grown in the Meliana field trial were monitored for antibiosis against Ralstonia solanacearum, whereas isolates derived from shoots of potatoes cultivated in the Cella trial were screened for antagonism against Ralstonia solanacearum and Rhizoctonia solani, and for 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase production. Determined antagonists were identified by 16S rRNA gene analysis. All potato traits hosted a cultivar-specific community of bacteria with antagonism against the pathogens and/or potential to produce ACC deaminase. Several antagonists obtained from the Cella field potatoes were also observed as ACC deaminase producers. Community profiling revealed a greater diversity differentiation between the senescent T4 lysozyme expressing and parental Desirée lines grown in the Cella field as compared to the variations between the three flowering conventional lines cultivated in the Meliana field trial. Effects of the two varying field sites and different vegetation stages were greater than those of T4 lysozyme when investigating the community composition of bacteria colonizing the shoots of the Desirée line cultivated in both field trials. 相似文献
8.
Protein kinase C phosphorylates the neurone-specific protein B-50 at a single Ser41 residue, which is also the point for a major proteolytic cleavage in vitro, and probably in vivo, that produces a B-50 phosphorylation-inhibiting N-terminal fragment and a large C-terminal metabolite B-60 (B-50(41-226]. The intact purified protein will bind to calmodulin in the absence of calcium, but the interaction has an absolute requirement for dephospho-B-50. In an attempt to unify two aspects of B-50 biochemistry, we have examined the interaction of B-50 binding to calmodulin and B-50 proteolysis. HPLC- and affinity-purified B-50 bound to calmodulin, but purified B-60 did not. To ensure that this effect was not due to the phosphorylation state of pure, isolated B-60, the metabolite was generated in vitro using a Triton extract of synaptosomal plasma membranes, which contains the as yet uncharacterized B-50 protease. B-60 derived from dephospho-B-50 also failed to bind calmodulin. The results demonstrate a direct connection between B-50 binding to calmodulin and B-50 proteolysis. The position of the proposed calmodulin-binding domain within intact B-50 is discussed in light of the failure of calmodulin to bind B-60. 相似文献
9.
10.
Nicholas W. VanKuren Henk C. den Bakker Joseph B. Morton Teresa E. Pawlowska 《Evolution; international journal of organic evolution》2013,67(1):207-224
Arbuscular mycorrhizal fungi (phylum Glomeromycota) are among the oldest and most successful symbionts of land plants. With no evidence of sexual reproduction, their evolutionary success is inconsistent with the prediction that asexual taxa are vulnerable to extinction due to accumulation of deleterious mutations. To explore why Glomeromycota defy this prediction, we studied ribosomal RNA (rRNA) gene evolution in the Claroideoglomus lineage and estimated effective population size, Ne, in C. etunicatum. We found that rRNA genes of these fungi exhibit unusual and complex patterns of molecular evolution. In C. etunicatum, these patterns can be collectively explained by an unexpectedly large Ne combined with imperfect genome‐wide and population‐level rRNA gene repeat homogenization. The mutations accumulated in rRNA gene sequences indicate that natural selection is effective at purging deleterious mutations in the Claroideoglomus lineage, which is also consistent with the large Ne of C. etunicatum. We propose that in the near absence of recombination, asexual reproduction involving massively multinucleate spores typical for Glomeromycota is responsible for the improved efficacy of selection relative to drift. We postulate that large effective population sizes contribute to the evolutionary longevity of Glomeromycota. 相似文献