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1.
E Seward C Hammond G Henderson 《Proceedings. Biological sciences / The Royal Society》1991,244(1310):129-135
The predominant consequences of mu-opioid-receptor activation are depression of both neuronal activity and transmitter release. Mu-Opioid agonists have previously been observed to increase a potassium conductance and to inhibit adenylate cyclase. We now report that activation of mu-opioid receptors directly decreases the N-type calcium-channel current in a differentiated, human neuroblastoma cell line (SH-SY5Y). The coupling between the mu-opioid receptor and the calcium channel involves a pertussis toxin-sensitive G protein and is independent of changes in adenylate cyclase activity. The inhibition of the calcium-channel current is voltage dependent because it is largely overcome by strong membrane depolarization. It is not associated with changes in the kinetics of current inactivation. Therefore, the mu-receptor belongs to the superfamily of G-protein-coupled, inhibitory neurotransmitter receptors which modulate the activity of calcium and potassium channels and adenylate cyclase. 相似文献
2.
Gerald R.V. Hammond Matthias P. Machner Tamas Balla 《The Journal of cell biology》2014,205(1):113-126
Polyphosphoinositides are an important class of lipid that recruit specific effector proteins to organelle membranes. One member, phosphatidylinositol 4-phosphate (PtdIns4P) has been localized to Golgi membranes based on the distribution of lipid binding modules from PtdIns4P effector proteins. However, these probes may be biased by additional interactions with other Golgi-specific determinants. In this paper, we derive a new PtdIns4P biosensor using the PtdIns4P binding of SidM (P4M) domain of the secreted effector protein SidM from the bacterial pathogen Legionella pneumophila. PtdIns4P was necessary and sufficient for localization of P4M, which revealed pools of the lipid associated not only with the Golgi but also with the plasma membrane and Rab7-positive late endosomes/lysosomes. PtdIns4P distribution was determined by the localization and activities of both its anabolic and catabolic enzymes. Therefore, P4M reports a wider cellular distribution of PtdIns4P than previous probes and therefore will be valuable for dissecting the biological functions of PtdIns4P in its assorted membrane compartments. 相似文献
3.
M L Greenlee J B Laub J M Balkovec M L Hammond G G Hammond D L Pompliano J H Epstein-Toney 《Bioorganic & medicinal chemistry letters》1999,9(17):2549-2554
Potent thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step. 相似文献
4.
Gerald R.V. Hammond 《Current biology : CB》2012,22(20):R869-R871
5.
E Hammond 《Experimental cell research》1970,59(3):359-370
6.
Diffusing capacity of the lung in Caucasians native to 3,100 m 总被引:2,自引:0,他引:2
A C DeGraff R F Grover R L Johnson J W Hammond J M Miller 《Journal of applied physiology》1970,29(1):71-76
7.
Human leukocyte typing sera of known specificities were used to test the leukocyte antigens of vervet monkeys. The results suggest that these leukocytes contained an antigen resembling the HL-A7 antigen of human leukocytes. This is similar to a previous observation with leukocytes from baboons. These findings are consistent with the suggestion that the 4a/4b complex is the precursor substance from which the other specificities have evolved. 相似文献
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10.
M. R. White R. L. Amborski A. M. Hammond Jr. G. F. Amborski 《In vitro cellular & developmental biology. Plant》1972,8(1):30-36
Summary Organ cultures containing the sex pheromone gland ofDiatraea saccharalis (F.) (sugarcane borer) were maintained for over 2 months. Juvenile hormone but not ecdysterone appeared to be essential for
the maintenance of integrity of the sex pheromone gland in the organ culture system. Muscles associated with these cultures
pulsated during hte entire culture period with or without juvenile hormone, suggesting that the hormone requirement was specific
for the sex pheromone gland and not a general requirement of the cells of the organ-cultured segment. 相似文献