全文获取类型
收费全文 | 1095篇 |
免费 | 102篇 |
出版年
2018年 | 10篇 |
2017年 | 9篇 |
2016年 | 16篇 |
2015年 | 29篇 |
2014年 | 36篇 |
2013年 | 51篇 |
2012年 | 33篇 |
2011年 | 43篇 |
2010年 | 38篇 |
2009年 | 37篇 |
2008年 | 46篇 |
2007年 | 32篇 |
2006年 | 39篇 |
2005年 | 48篇 |
2004年 | 33篇 |
2003年 | 27篇 |
2002年 | 30篇 |
2001年 | 30篇 |
2000年 | 24篇 |
1999年 | 20篇 |
1998年 | 15篇 |
1997年 | 22篇 |
1996年 | 15篇 |
1995年 | 10篇 |
1994年 | 12篇 |
1993年 | 17篇 |
1992年 | 17篇 |
1991年 | 16篇 |
1990年 | 17篇 |
1989年 | 17篇 |
1988年 | 32篇 |
1987年 | 10篇 |
1986年 | 19篇 |
1985年 | 13篇 |
1984年 | 9篇 |
1982年 | 28篇 |
1981年 | 9篇 |
1980年 | 12篇 |
1979年 | 23篇 |
1978年 | 20篇 |
1977年 | 13篇 |
1976年 | 18篇 |
1974年 | 10篇 |
1973年 | 19篇 |
1972年 | 24篇 |
1971年 | 21篇 |
1970年 | 20篇 |
1969年 | 16篇 |
1968年 | 10篇 |
1967年 | 8篇 |
排序方式: 共有1197条查询结果,搜索用时 15 毫秒
1.
2.
3.
The aggregation of amyloid-β protein (Aβ) in vivo is a critical pathological event in Alzheimer's disease. Although more and more evidence shows that the intermediate oligomers are the primary neurotoxic species in Alzheimer's disease, the particular structural features responsible for the toxicity of these intermediates are poorly understood. We measured the peptide level solvent accessibility of multiple Aβ(1-40) aggregated states using hydrogen exchange detected by mass spectrometry. A gradual reduction in solvent accessibility, spreading from the C-terminal region to the N-terminal region was observed with ever more aggregated states of Aβ peptide. The observed hydrogen exchange protection begins with reporter peptides 20-34 and 35-40 in low molecular weight oligomers found in fresh samples and culminates with increasing solvent protection of reporter peptide 1-16 in long time aged fibrillar species. The more solvent exposed structure of intermediate oligomers in the N-termini relative to well-developed fibrils provides a novel explanation for the structure-dependent neurotoxicity of soluble oligomers reported previously. 相似文献
4.
5.
Timothy J. French Anthony W. Good T. Norman Palmer Mary C. Sugden 《Bioscience reports》1985,5(9):729-734
The in vivo effects of dexamethasone administration on liver and extrahepatic tissue carnitine concentrations were assessed in 48-h-starved rats. In heart and kidney, but not in liver, dexamethasone significantly increased total carnitine concentration. Acute (2.5 h) treatment with 2-tetradecylglycidate (TDG), a specific inhibitor of carnitine palmitoyl transferase 1, not only increased total hepatic carnitine concentrations, but also permitted an effect of dexamethasone (a further increase in hepatic carnitine concentration). The results are discussed in terms of acute (substrate-mediated) and chronic (hormonal) control of carnitine turnover. 相似文献
6.
7.
Theory of the adhesion of cells and the spontaneous sorting-out of mixed cell aggregates 总被引:3,自引:0,他引:3
R J Good 《Journal of theoretical biology》1972,37(3):413-434
8.
9.
In cancer and other therapeutic research, an interpretation of median survival times can and should take cure into account. With this qualification, an analysis of recently published data provides further statistically significant evidence in favor of cancer chronotherapy as compared to homeostatic therapy. 相似文献
10.