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1.
Samaneh Shojaei Seyed Mahmoud Hashemi Hossein Ghanbarian Mohammad Salehi Samira Mohammadi-Yeganeh 《Journal of cellular physiology》2019,234(4):3394-3409
Mesenchymal stem cells (MSCs) are multipotent cells with the potential to differentiate into different cell types. Owing to their immunosuppressive and anti-inflammatory properties, they are widely used in regenerative medicine, but they have a dual effect on cancer progression and exert both growth-stimulatory or -inhibitory effects on different cancer types. It has been proposed that these controversial effects of MSC in tumor microenvironment (TME) are mediated by their polarization to proinflammatory or anti-inflammatory phenotype. In addition, they can polarize the immune system cells that in turn influence tumor progression. One of the mechanisms involved in the TME communications is extracellular vesicles (EVs). MSCs, as one of cell populations in TME, produce a large amount of EVs that can influence tumor development. Similar to MSC, MSC-EVs can exert both anti- or protumorigenic effects. In the current study, we will investigate the current knowledge related to MSC role in cancer progression with a focus on the MSC-EV content in limiting tumor growth, angiogenesis, and metastasis. We suppose MSC-EVs can be used as safe vehicles for delivering antitumor agents to TME. 相似文献
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Ghaheri Matin Kahrizi Danial Bahrami Gholamreza Mohammadi-Motlagh Hamid-Reza 《Molecular biology reports》2019,46(1):7-16
Molecular Biology Reports - Stevia rebaudiana produces sweet steviol glycosides that are 300 times sweeter than sugar and have the beneficial effects on human health including anti-hyperglycaemic.... 相似文献
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Seyed Sajad Mohseni Salehi Monfared Shirin Pournourmohammadi 《Biological trace element research》2010,133(2):236-241
Islet transplantation has become a promising treatment in the therapy of type 1 diabetes. Its function improvement, after
isolation and before transplantation, is crucial because of their loss both in number and function of islets after isolation
procedures. Trace elements sodium orthovanadate (SOV) and sodium molybdate (SM), as well as medicinal plant Teucrium polium L. (TP), showed and possessed high beneficial antioxidative potential and even hypoglycemic properties via their effect on
islets. We evaluated the effect of these components in combination on cultured islet function in order to improve pancreatic
islet transplantation. Rat pancreatic islets were cultured for 24 h then incubated with different concentrations of TP (0.01
and 0.1 mg/mL) alone and in combination with SOV (1 mM) or SM (1 mM). Insulin concentration in buffer media was measured as
islet secretory function. Administration of TP (0.01 mg/mL), SM, and SOV alone or in combination with each other significantly
increased insulin secretion at high glucose concentration (16.7 mM); insulin secretion was significantly greater in the group
containing both TP and SM than other treated groups (p < 0.05). The combination of the mentioned trace elements especially molybdate with TP could improve islet cells function before
transplantation. 相似文献
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Phyllody is a destructive disease of sesame (Sesamum indicum L.) in Iran. The major symptoms of the disease are floral virescence, phyllody and proliferation. Other symptoms which sometimes accompany the disease are yellowing, cracking of seed capsules, germination of seeds in the capsules and formation of dark exudates on the foliage. Light microscopy of hand-cut sections of sesame and colza (Brassica napus L. cv. Oro) stems treated with Dienes' stain showed blue areas in the phloem region of phyllody infected plants. Mycoplasma-like bodies were found in the sieve cells of infected sesame stems when thin sections were examined m an electron microscope. Sesame phyllody was successfully transmitted from sesame to sesame by grafting. Among various leafhoppers collected in sesame fields only Neoaliturus haematoceps transmitted the disease. This is the first report on the identification of a Mycoplasma-like organism (MLO) as the cause of sesame phyllody and N. haematoceps as an MLO vector in Iran. In host range studies using the leafhopper vector, only B. napus cv. Oro, Lepidium sativum, Catharanthus roseus, Lactuca sp. and Portulaca oleracea, but not 17 other species, developed symptoms. The species of vector and host range of MLO indicate that sesame phyllody in Iran is different from that reported in India and Upper Volta. 相似文献
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Mohammad Asadi Mohammad Hossein Motevaselian Alireza Moradzadeh Leily Majidi Mohammadreza Esmaeilirad Tao Victor Sun Cong Liu Rumki Bose Pedram Abbasi Peter Zapol Amid P. Khodadoust Larry A. Curtiss Narayana R. Aluru Amin Salehi‐Khojin 《Liver Transplantation》2019,9(9)
Conversion of CO2 to energy‐rich chemicals using renewable energy is of much interest to close the anthropogenic carbon cycle. However, the current photoelectrochemical systems are still far from being practically feasible. Here the successful demonstration of a continuous, energy efficient, and scalable solar‐driven CO2 reduction process based on earth‐abundant molybdenum disulfide (MoS2) catalyst, which works in synergy with an inexpensive hybrid electrolyte of choline chloride (a common food additive for livestock) and potassium hydroxide (KOH) is reported. The CO2 saturated hybrid electrolyte utilized in this study also acts as a buffer solution (pH ≈ 7.6) to adjust pH during the reactions. This study reveals that this system can efficiently convert CO2 to CO with solar‐to‐fuel and catalytic conversion efficiencies of 23% and 83%, respectively. Using density functional theory calculations, a new reaction mechanism in which the water molecules near the MoS2 cathode act as proton donors to facilitate the CO2 reduction process by MoS2 catalyst is proposed. This demonstration of a continuous, cost‐effective, and energy efficient solar driven CO2 conversion process is a key step toward the industrialization of this technology. 相似文献
10.
Zarrati Mitra Raji Lahiji Mahsa Salehi Eisa Yazdani Bahareh Razmpoosh Elham Shokouhi Shoormasti Raheleh Shidfar Farzad 《Probiotics and antimicrobial proteins》2019,11(4):1202-1209
Probiotics and Antimicrobial Proteins - Data on the effects of probiotics on adipokines such as omentin-1, nesfatin-1, and adropin are limited. The aim of this study was to evaluate the effects of... 相似文献