全文获取类型
收费全文 | 503篇 |
免费 | 39篇 |
国内免费 | 1篇 |
出版年
2019年 | 3篇 |
2018年 | 4篇 |
2017年 | 3篇 |
2016年 | 8篇 |
2015年 | 13篇 |
2014年 | 25篇 |
2013年 | 17篇 |
2012年 | 36篇 |
2011年 | 25篇 |
2010年 | 34篇 |
2009年 | 14篇 |
2008年 | 40篇 |
2007年 | 25篇 |
2006年 | 24篇 |
2005年 | 20篇 |
2004年 | 29篇 |
2003年 | 28篇 |
2002年 | 22篇 |
2001年 | 4篇 |
2000年 | 11篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1994年 | 3篇 |
1993年 | 8篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1988年 | 3篇 |
1987年 | 8篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 8篇 |
1980年 | 5篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1977年 | 6篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1974年 | 5篇 |
1973年 | 6篇 |
1972年 | 4篇 |
1971年 | 7篇 |
1970年 | 3篇 |
1967年 | 2篇 |
1961年 | 2篇 |
1938年 | 2篇 |
1936年 | 3篇 |
排序方式: 共有543条查询结果,搜索用时 15 毫秒
1.
2.
STRUCTURE OF THE PHOTOSYNTHETIC APPARATUS IN PROTEIN-EMBEDDED CHLOROPLASTS 总被引:1,自引:1,他引:0 下载免费PDF全文
Garth L. Nicolson 《The Journal of cell biology》1971,50(1):258-263
3.
4.
5.
Harold L. Asch Robert Z. Vinci Jae Y. Chang Farah Natoli Daniel L. Stoler Garth R. Anderson Bonnie B. Asch 《Cell biology international》1993,17(10):961-968
Amplified expression of the endogenous retrotransposons, intracisternal A particles (IAPs) and murine leukemia virus-related elements (MLVEs), along with decreased expression of VL30 elements frequently occurs during mouse mammary tumorigenesis. We have now analyzed the expression of these retroelements during the normal developmental and differentiation cycle of the mammary gland as found in virgin, pregnant, lactating, and post-lactation adult female BALB/c mice. Retrotransposon expression was either unchanged or decreased during the progressive stages of the cycle compared to virgin tissue. Likewise, growth of mammary epithelial cells in primary culture had little or no effect on expression of IAPs, MLVEs and VL30 sequences. Thus, the dramatic changes involving these retrotransposons in many mouse mammary tumors appear unrelated to any normal state. 相似文献
6.
7.
8.
Aggregation-prone proteins associated with neurodegenerative disease, such as α synuclein and β amyloid, now appear to share key prion-like features with mammalian prion protein, such as the ability to recruit normal proteins to aggregates and to translocate between neurons. These features may shed light on the genesis of stereotyped lesion development patterns in conditions such as Alzheimer disease and Lewy Body dementia. We discuss the qualifications of tau protein as a possible “prionoid” mediator of lesion spread based on recent characterizations of the secretion, uptake and transneuronal transfer of human tau isoforms in a variety of tauopathy models, and in human patients. In particular, we consider (1) the possibility that prionoid behavior of misprocessed tau in neurodegenerative disease may involve other aggregation-prone proteins, including PrP itself, and (2) whether “prionlike” tau lesion propagation might include mechanisms other than protein-protein templating. 相似文献
9.
10.
Scott Davis Stephanie Propp Susan M. Freier Laura E. Jones Martin J. Serra Garth Kinberger Balkrishen Bhat Eric E. Swayze C. Frank Bennett Christine Esau 《Nucleic acids research》2009,37(1):70-77
Chemically modified antisense oligonucleotides (ASOs) are widely used as a tool to functionalize microRNAs (miRNAs). Reduction of miRNA level after ASO inhibition is commonly reported to show efficacy. Whether this is the most relevant endpoint for measuring miRNA inhibition has not been adequately addressed in the field although it has important implications for evaluating miRNA targeting studies. Using a novel approach to quantitate miRNA levels in the presence of excess ASO, we have discovered that the outcome of miRNA inhibition can vary depending on the chemical modification of the ASO. Although some miRNA inhibitors cause a decrease in mature miRNA levels, we have identified a novel 2′-fluoro/2′-methoxyethyl modified ASO motif with dramatically improved in vivo potency which does not. These studies show there are multiple mechanisms of miRNA inhibition by ASOs and that evaluation of secondary endpoints is crucial for interpreting miRNA inhibition studies. 相似文献