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1.
Chungwen Wei Eugene Storozynsky A. J. McAdam Kun-Yun Yeh Brian R. Tilton Richard A. Willis Richard K. Barth R. John Looney Edith M. Lord J. G. Frelinger 《Cancer immunology, immunotherapy : CII》1996,42(6):362-368
Human prostate-specific antigen (PSA) has a highly restricted tissue distribution. Its expression is essentially limited
to the epithelial cells of the prostate gland. Moreover, it continues to be synthesized by prostate carcinoma cells. This
makes PSA an attractive candidate for use as a target antigen in the immunotherapy of prostate cancer. As a first step in
characterizing the specific immune response to PSA and its potential use as a tumor-rejection antigen, we have incorporated
PSA into a well-established mouse tumor model. Line 1, a mouse lung carcinoma, and P815, a mouse mastocytoma, have been transfected
with the cDNA for human PSA. Immunization with a PSA-expressing tumor cell line demonstrated a memory response to PSA which
protected against subsequent challenge with PSA-expressing, but not wild-type, tumors. Tumor-infiltrating lymphocytes could
be isolated from PSA-expressing tumors grown in naive hosts and were specifically cytotoxic against a syngeneic cell line
that expressed PSA. Immunization with tumor cells resulted in the generation of primary and memory cytotoxic T lymphocytes
(CTL) specific for PSA. The isolation of PSA-specific CTL clones from immunized animals further demonstrated that PSA can
serve as a target antigen for antitumor CTL. The immunogenicity studies carried out in this mouse tumor model provide a rationale
for the design of methods to elicit PSA-specific cell-mediated immunity in humans.
Received: 4 April 1996 / Accepted: 31 May 1996 相似文献
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3.
Dr. Edith Raadts 《Planta》1952,40(5):419-430
Zusammenfassung Mittels der Diffusionsmethode wurde für den aufsteigenden inaktiven Wuchsstoff der Haferkoleoptile ein Molekulargewicht ungefähr um 170 bestimmt. Das entspricht annähernd dem der -Indolessigsäure von 175. Der inaktive Wuchsstoff ist daher jedenfalls ein Derivat dieser Säure. Er ist eine neutrale Substanz und gegen Säuren und Laugen empfindlich.Mit 1 Textabbildung. 相似文献
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The zygopterid fern Etapteris leclercqii sp. n. is described from Lower Pennsylvanian age coal balls from the Lewis Creek, Kentucky, locality. Isolated petioles extend up to 15.0 cm in length and 5.0 mm in diam; no lateral axes have been observed. The clepsydroid-shaped petiole trace is characterized by lateral arms that sharply taper and by the production of peripheral loops prior to the separation of pinna traces from the stele. Large irregularly shaped multicellular hairs are randomly scattered over the surface of the petioles. When compared with other currently recognized zygopterid ferns, E. leclercqii appears most similar to Metaclepsydropsis duplex. Based on the configuration of the leaf trace and the occurrence of peripheral loops, it is suggested that E. leclercqii may represent the most primitive species of the genus known to date. 相似文献
6.
A. Buchinger 《Genetica》1933,15(4):299-342
Ohne ZusammenfassungMit 12 Abbildungen 相似文献
7.
A mutant of Neurospora crassa (pm-nbg27) was isolated on the basis of its resistance to p-fluoro-phenylalamine on ammonium-deficient Vogel's medium. This mutant was found to be devoid of both conidial and post-conidial (after 180 min of preincubation) transport acitvity of all amino acids.Genetic analysis exhibiting of pm-nbg27 by crossing it to wild-type (74A) resulted in the predicted segregants exhibiting transport characteristics of pm-n, pm-b, pm-g, pm-nb, pm-ng, pm-bg and parental types.The above observations confirm the postulated general amino acids permease system as well as a single genetic locus control of that activity. 相似文献
8.
A. Buchinger 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1937,9(6-7):152-157
Ohne Zusammenfassung 相似文献
9.
Edith Willimzik 《Zoomorphology》1930,18(4):669-700
Ohne Zusammenfassung 相似文献
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