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Summary An investigation was carried out in order to study the effect of salts namely NaC1 and Na2SO4 on the rate of translocation of photosynthates in pigeonpea, at the pod filling stage. At the concentration of 10 EC NaC1
only 17% of the14C assimilates are translocated from the source leaf to the other parts of the plant. Out of this pods receive about 8%. On
the other hand even at a concentration of 15 EC Na2SO4 about 30% of the total14C assimilates get translocated and out of this pods receive about 12%. From this it may be concluded that under salt-stress
conditions the rate of translocation of photosynthates is adversely affected and between the two salts, NaC1 was discovered
to have a marked inhibitory effect. 相似文献
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S. S. Shishvan A. Vigliotti V. S. Deshpande 《Biomechanics and modeling in mechanobiology》2018,17(6):1631-1662
Cells are quintessential examples of out-of-equilibrium systems, but they maintain a homeostatic state over a timescale of hours to days. As a consequence, the statistics of all observables is remarkably consistent. Here, we develop a statistical mechanics framework for living cells by including the homeostatic constraint that exists over the interphase period of the cell cycle. The consequence is the introduction of the concept of a homeostatic ensemble and an associated homeostatic temperature, along with a formalism for the (dynamic) homeostatic equilibrium that intervenes to allow living cells to evade thermodynamic decay. As a first application, the framework is shown to accurately predict the observed effect of the mechanical environment on the in vitro response of smooth muscle cells. This includes predictions that both the mean values and diversity/variability in the measured values of observables such as cell area, shape and tractions decrease with decreasing stiffness of the environment. Thus, we argue that the observed variabilities are inherent to the entropic nature of the homeostatic equilibrium of cells and not a result of in vitro experimental errors. 相似文献
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Rong Chen Alex A Morgan Joel Dudley Tarangini Deshpande Li Li Keiichi Kodama Annie P Chiang Atul J Butte 《Genome biology》2009,9(12):R170
Background
Candidate single nucleotide polymorphisms (SNPs) from genome-wide association studies (GWASs) were often selected for validation based on their functional annotation, which was inadequate and biased. We propose to use the more than 200,000 microarray studies in the Gene Expression Omnibus to systematically prioritize candidate SNPs from GWASs. 相似文献5.
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Medha Raina Adil Moghal Amanda Kano Mathew Jerums Paul D. Schnier Shun Luo Rohini Deshpande Pavel V. Bondarenko Henry Lin Michael Ibba 《The Journal of biological chemistry》2014,289(25):17780-17790
Quality control operates at different steps in translation to limit errors to approximately one mistranslated codon per 10,000 codons during mRNA-directed protein synthesis. Recent studies have suggested that error rates may actually vary considerably during translation under different growth conditions. Here we examined the misincorporation of Phe at Tyr codons during synthesis of a recombinant antibody produced in tyrosine-limited Chinese hamster ovary (CHO) cells. Tyr to Phe replacements were previously found to occur throughout the antibody at a rate of up to 0.7% irrespective of the identity or context of the Tyr codon translated. Despite this comparatively high mistranslation rate, no significant change in cellular viability was observed. Monitoring of Phe and Tyr levels revealed that changes in error rates correlated with changes in amino acid pools, suggesting that mischarging of tRNATyr with noncognate Phe by tyrosyl-tRNA synthetase was responsible for mistranslation. Steady-state kinetic analyses of CHO cytoplasmic tyrosyl-tRNA synthetase revealed a 25-fold lower specificity for Tyr over Phe as compared with previously characterized bacterial enzymes, consistent with the observed increase in translation error rates during tyrosine limitation. Functional comparisons of mammalian and bacterial tyrosyl-tRNA synthetase revealed key differences at residues responsible for amino acid recognition, highlighting differences in evolutionary constraints for translation quality control. 相似文献