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1.
Cornelis L Verweij 《Arthritis research & therapy》2009,11(3):115-2
Tumor necrosis factor (TNF) antagonists are approved worldwide for the treatment of rheumatoid arthritis (RA). Clinical experience
revealed that TNF-blocking therapy is effective for only approximately two thirds of patients, reflecting that there are 'responders'
as well as 'nonresponders'. Given the destructive nature of RA, the risk of adverse effects, and considerable costs for therapy,
there is a strong need to make predictions on success before the start of therapy. In the current issue of Arthritis Research & Therapy, Hueber and colleagues become the first to present a multi-parameter serum protein biomarker set that has predictive value
prior to the start of anti-TNF treatment. Ultimately, this finding may contribute to a personalized form of medicine, whereby
a specific therapy will be applied that is best suited to an individual patient. 相似文献
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Brigitta M. N. Brinkman Eric L. Kaijzel Tom W. J. Huizinga Marius J. Giphart Ferdinand C. Breedveld Cornelis L. Verweij 《Human genetics》1995,96(4):493-493
We have identified a C-insertion polymorphism in the 5'UTR of the first exon of the human tumor necrosis factor alpha (TNFA) gene. TNFA is a cytokine that plays an important role in the inflammatory response. 相似文献
4.
Herbert Budzikiewicz Mathias Schäfer Diana Uría Fernández Sandra Matthijs Pierre Cornelis 《Biometals》2007,20(2):135-144
Characteristic fragment ions of the various chromophores of the pyoverdin siderophore family obtained by collision activated
dissociation of the [M+2H]2+ ions are reported allowing unambiguous identification. Tandem mass spectrometrical studies revealed the existence of the
first example of a ferribactin with a succinamide side chain, and they add some information to the problem in which way a
malic acid side chain is attached to the chromophore. 相似文献
5.
In Argentina, five genera and 14 species are recorded in the subfamilies Prostemmatinae and Nabinae: Hoplistoscelis sordidus Reuter, Lasiomerus constrictus Champion, Metatropiphorus alvarengai Reuter, Nabis argentinus Meyer-Dür, Nabis (Tropiconabis) capsiformis Germar, Nabis faminei Stål, Nabis paranensis Harris, Nabis punctipennis Blanchard, Nabis roripes Stål, Nabis setricus Harris, Nabis tandilensis Berg, Pagasa (Pagasa) costalis Reuter, Pagasa (Lampropagasa) fuscipennis Reuter and Pagasa (Pagasa) signatipennis Reuter. 相似文献
6.
Summary A quantitative histochemical assay for NADPH-ferrihemoprotein (P450) reductase had been developed. For optimal activity, it is necessary to use a relatively electropositive tetrazolium salt such as neotetrazolium chloride as the final acceptor. The apparentK
m of the reaction is 0.83 mM. Its specificity has been proven in two ways: (i) activity is increased selectively in the pericentral zone of liver from rats treated with phenobarbitone, an inducer of the reductase, though not in liver of rats injected with 3-methylcholanthrene, which induces NAD(P)H dehydrogenase; (ii) it is competitively inhibited by NADP+ (K
i=1.50mm) though unaffected by dicumarol, an inhibitor of NAD(P)H dehydrogenase activity. An NADP+ concentration ten times greater than the substrate concentration inhibits the histochemical reaction and the reaction in a microsomal fraction assayed biochemically to the same degree (70% inhibition). The amount of inhibition is independent of temperature, of the zone of the acinus and of the treatment of the animal.Continuous microdensitometric monitoring of the reaction product as it is formed has shown that the specific reaction is linear with incubation up to 10 min, thus allowing end-point measurements to be used for cytophotometric analysis. 相似文献
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A number of d-galactopyranosides bearing aromatic substituents have been prepared, and their binding to immunoglobulin J539 (Fab') has been studied. It appears that the main contribution of the 6-O-aromatic moiety to binding arises from the fact that it imparts an increased hydrophobicity to the ligand, causing a decrease in its hydration (solubility) that results in a greater free-energy of binding. In the d-galactosides having an aromatic aglycon, the phenyl group appears to partake in actual interactions with the protein. 相似文献
9.
Discovery of a Novel Insect Neuropeptide Signaling System Closely Related to the Insect Adipokinetic Hormone and Corazonin Hormonal Systems 总被引:1,自引:0,他引:1
10.